6-氨甲基喹啉的合成

Synthesis of 6-aminomethylquinoline

目的改进6-氨甲基喹啉的合成工艺。方法以6-甲基喹啉、溴代琥珀酰亚胺、邻苯二甲酰亚胺钾、水合肼为原料,经溴代和Gabriel反应得到6-氨甲基喹啉。结果目标化合物经MS、1H-NMR确证化学结构,总产率达到47.5%。结论为6-甲基喹啉的制备提供了一条较为合理的工艺路线。

Objective To improve the synthesis of 6-aminomethylquinoline. Methods The 6-aminomethylquinoline was synthesized by using 6-methylquinoline,N-bromosuccinimide potassium phthalimide, and hydrazine hydrate as materials by bromination reaction and Gabriel reaction. Results The chemical structure of the target compound was confirmed by MS, 1H-NMR. The overall yield of title compound was 47.5%. Conclusions This article can provide a more reasonable route for the production process of 6-aminomethylquinoline.