阿托伐他汀对不稳定型心绞痛患者血清超敏C反应蛋白水平影响的Meta分析

Analysis of Atorvastatin influence on serum high-sensitivity C-reactive protein level in patients with unstable angina

目的分析阿托伐他汀对不稳定型心绞痛患者血清超敏C反应蛋白(hs-CRP)水平的影响。方法通过计算机检索PUBMED、OVID、中国知网总库、万方数据知识服务平台、维普期刊资源整合服务平台,获得具有完整数据的关于阿托伐他汀对不稳定型心绞痛患者血清hs-CRP水平影响的随机对照研究,并用RevMan5.2.6软件对数据进行统计学分析。结果共纳入13个临床随机对照研究。Meta分析显示,通过阿托伐他汀治疗后,试验组患者血清hs-CRP水平下降更明显,差异有统计学意义(Z=6.53,P<0.01),且亚组1、2的Meta分析结果趋势与总体相同;大剂量组与小剂量组相比,患者血清hs-CRP水平下降更明显,差异有统计学意义(Z=7.61,P<0.01)。结论阿托伐他汀能有效降低不稳定型心绞痛患者的血清hs-CRP水平。

Objective To analyze the Atorvastatin influence on serum high-sensitivity C-reactive protein （hs-CRP） level in patients with unstable angina and make a meta-analysis. Methods We selected articles about the effect of Atorvastatin on serum hs-CRP level in patients with unstable angina, collected detailed data, and searched in such databases as ＂PubMed, OVID, CNKI, Wanfang, Weipu＂, and used RevMan5. 2.6 to deal with the data. Results Totally, 13 contrastive studies were selected at random. Meta-analysis, with statistic significance, indicates that the serum hs-CRP level of patients, in Atorvastatin group, is much lower than the controlled group after therapy. The results of subgroupl and subgroup2 are similar with the main＇s and the serum hs-CRP level of patients is much lower in the groups with large dose atorvastatin than the groups with small dose atorvastatin. Conclusion Atorvastatin can reduce effectively hs- CRP level in patients with unstable angina efficiently.