偏头痛神经元特异性烯醇化酶的变化及其影响因素的研究

Levels of neuron specific enolase in patients with migraine and associated factors

目的探讨神经元特异性烯醇化酶(neuron specific enolase,NSE)在偏头痛患者中的变化及影响因素。方法选择宿州市立医院神经科门诊就诊的偏头痛患者59例(患者组)及健康体检中心正常人33例(对照组)。患者组根据偏头痛发作时程分为发作期和发作间期。根据先兆分为有先兆偏头痛(migraine with aura,MwA)组和无先兆偏头痛(migraine without aura,MwoA)组。在偏头痛患者发作期及发作间期均行血清NSE测定,对照组只行一次血清NSE测定。使用SPSS 16.0对患者资料进行t检验、多重线性回归分析。结果和对照组相比,偏头痛患者发作期及发作间期NSE水平均显著升高(t=7.196,P<0.01;t=3.907,P<0.01);与发作间期相比,发作期血清NSE显著升高(t=13.220,P<0.01);偏头痛发作期及发作间期血清NSE的影响因素均是持续时间(h)和发作频率(次/月);伴有先兆的偏头痛患者与不伴有先兆的偏头痛患者相比血清NSE差异没有统计学意义(t=0.157,P=0.876;t=0.140,P=0.889)。结论偏头痛发作期及发作间期可能伴有神经元损伤,神经元损伤程度与头痛持续时间及头痛发作频率相关。

Objective To study changes of neuron specific enolase（NSE） levels in patients with migraine and associated factors. Methods Thirty three normal subjects from health physical examination center（ control group） and 59 patients with migraine （migraine group） were recruited in this study. According to the course of disease, the patients with migraine were divided into ictal period and interictal periods. According to whether an aura is present or not, migraine group was di- vided into groups with aura （ MwA ） and without aura （MwoA）. The serum levels of NSE in control group and migraine group（ ietal and interietal periods） were measured. Statistical analysis was performed using t test and multiple linear re- gressions by the software package SPSS 16.0 for Windows. Results The serum NSE levels in both the ictal and interictal periods increased in the migraine group as compared to the control group（ t = 7. 196, P 〈 0.01;t = 3. 907,P 〈 0.01 ） ;the serum NSE levels in the ictal period was significantly higher than that in the interictal period（ t = 13. 220 ,P 〈 0.01 ） ;Associated factors of the serum NSE levels in both ictal and interictal periods were the duration of attack（hour） and attack frequency（days/month） ;There were no significant differences in serum NSE levels between MwA and MwoA during the migraine attack as well as during the pain-free interval（t =0. 157,P =0. 876;t =0. 140,P =0. 889）. Conclusion The migraine might be associated with neuronal damage in the brain during the ictal and interietal periods. The neuronal damage is correlated to the duration time and frequency of migraine attack.