骨显像半定量分析在骨质疏松疗效监测中的应用

Value of bone scan semi-quantitative analysis in monitoring osteoporosis therapy efficacy

目的探讨^99yc^m-MDP骨显像半定量分析在骨质疏松疗效早期监测中的应用价值。方法选取2011年1月～2013年10月浙江省金华市中心医院收治的18例骨质疏松妇女，年龄50—72岁。阿仑膦酸钠治疗前及治疗后3个月分别进行^99yc^m-MDP全身骨显像和骨密度值测量，利用感兴区（ROI）技术获取骨显像的L1～L4和股骨颈ROI比值并与治疗前进行对比，进行骨代谢骨质半定量分析。结果骨质疏松患者阿仑膦酸钠治疗后3个月骨密度显示，L1～L4及股骨颈骨密度值均高于治疗前，且L3和L4骨密度值与治疗前比较，差异有统计学意义（P〈0．05）。治疗3个月后骨显像显示，L2～L4及股骨颈ROI比值均明显低于治疗前，差异有统计学意义（P〈0．05）。结论^99yc^m-MDP骨显像半定量分析能准确反映骨质疏松治疗后骨代谢的早期变化，对治疗效果监测中具有潜在应用价值。

Objective To explore application value of ^99yc^m-MDP bone scanning semi-quantitative analysis in monitoring the osteoporosis therapy efficacy in early-stage. Methods From January 2011 to October 2013, in Central Hospital of Jinhua City of Zhejiang Province, 18 women with osteoporotic were chosen, and they were 50-72 years old. Before and 3 months after the Alendronate treatment, they were respectively checked with ^99yc^m-MDP bone scanning and bone mineral density （BMD） measurement. The regions of interest （RO1） technology was used for obtaining the radioactive counts ratios （ROI ratios） of L1-I4 and femoral neck. BMD and ROI ratios of L1-L4 and femoral neck before and 3 months after the treatmnet were compared. Results The BMD of L1-L4 and femoral neck after 3-month treatment with Alendronate were higher than those before the treatment, and BMD of L3-L4 were compared with those before the treat- ment, the differences were statistically significant （P 〈 0.05）. Bone scanning showed that ROI ratios of L1-L4 and femoral neck after the treatment were lower than those before the treatment, the differences were statistically significant （P 〈 0.05）. Conclusion ^99yc^m-MDP bone%canning semi-quantitative analysis can accurately reflect the early changes of bone metabolism after therapy, which has a potential application value in monitoring the therapy efficacy.