不同种类前列腺素类滴眼液治疗原发性开角型青光眼的降眼压效果对比

Effects comparison of tree prostaglandin eyedrops in reducing open-angle glaucoma intraocular pressure

目的比较拉坦前列素、曲伏前列素及贝美前列素滴眼液治疗原发性开角型青光眼患者6周后的降眼压的效果。方法选取2012年10月～2013年10月于承德市中心医院门诊就诊的原发性开角型青光眼患者78例（141只眼）。将其按照给药方法分为三组，每组均为26例，其中Ⅰ组给予拉坦前列素滴眼液（47只眼）；Ⅱ组给予曲伏前列素滴眼液（47只眼）；Ⅲ组给予贝美前列素滴眼液（47只眼），三组均每日不同时间点滴眼Ⅰ次，疗程为4周．测量比较三组用药前后的24h内、不同时间点的眼压以及用药前后4周内眼压。结果三组治疗前眼压比较，差异无统计学意义（P〉0．05）；三组治疗后24h内各时间点眼压均明显下降，差异有统计学意义（P〈0．05），但各组间眼内压比较，差异无统计学意义（P〉0．05）；三组用药后4周眼压比较，差异无统计学意义（P〉0．05）。结论采用拉坦前列素、曲伏前列素及贝美前列素滴眼液治疗原发性开角型青光眼患者4周后的降眼压的效果显著．且三种滴眼液治疗效果无明显差异。

Objective To compare the effect of latanoprost, travoprost and bimatoprost on the 24 h intraocular pressure （lOP） curve in open-angle glaucoma patients. Methods 78 patients with open-angle glaucoma were randomly divided into 3 groups according to different kinds of administration methods, with 26 cases in each group. Group Ⅰ, group Ⅱ and group Ⅲ were treated once daily with latanoprost, travoprost and bimatoprost eyedrops for four weeks,respectively. Be- fore and 4 weeks after the treatment, IOP was measured and compared at 4 time opints in 24 hours. Results There was no difference of IOP before the treatment among the three groups （P 〉 0.05）, but IOP became lower at various time points among the three groups 4 weeks after the treatment, the differences were statistically significant （P 〈 0.05）. There were no significant differences of IOP among the three groups （P 〉 0.05）. There was no significant difference of IOP a- mong the three groups after 4 weeks treatment （P 〉 0.05）. Conclusion The method is quite obvious by using latanoprost, travoprost and bimatoprost on the IOP in open-angle glaucoma patients.