2010年～2013年461份药品不良反应报告的分析

Analysis of 461 ADR Case RePorts During 2010--2013

目的：分析本院2010年～2013年药品不良反应发生特点与规律，为临床安全合理用药提供依据。方法运用Microft Office Excel和SPSS 19.0等软件，对我院2010年8月至2013年12月上报到广东省不良反应监测中心的461份药品不良反应报告进行统计，分析其患者的性别和年龄分布、ADR类型及不同剂型药物的分布情况等。结果 ADR发生的性别分布偏向男性患者（60.95%），这一偏向比2010年8月前更为明显（P＜0.01），尤其是60岁以上的男性患者；注射剂的ADR发生率最高，占86.64%，其次口服制剂，占13.16%，其中口服剂型发生的ADR中严重的28例（43.07%）；引起ADR前3类药物分别是抗微生物药物、中成药、中枢神经系统药。结论重视ADR的监测和报告工作，加强ADR知识的培训，对已知的引起严重不良反应的怀疑药物应重点监控，合理应用抗微生物药物和中成药，减少ADR的发生，保证患者用药安全。

Objective To analyse the Adverse drug reaction occurrence characteristics and rules in our hosPital during 2010~2013. To Provide a basis for clinical rational drug use. Method Use Microft Office Excel and SPSS 19.0, statistics 461 ADR case reports in our hosPital from 2010 August to 2013 December in Guangdong province reported adverse reaction monitoring center. Analysis of the distribution of age and sex of the patients. ADR type and different forms of drug distribution. Result Gender distribution biased men Patients of ADR （60.95%）.This tendency is more obvious than in 2010 August（P〈0.01）. Especially the men patients over the age of 60. Injection of the highest incidence rate of ADR（60.95%）.Secondly incidence of oral dosage forms, Included 28 case of severe ADR（43.07%）.The to P 3 caused ADR are antimicrobial drugs, traditional chinese medicine and central nervous system drugs. Conclusion Pay attention to the ADR monitoring and reporting. Strengthen the ADR knowledge training. Should focu on monitoring of the suspected drugs known to cause serious adverse reactions. The rational use of antimicrobial drugs and traditional chinese medicine. Reduction of the incidence of ADR, to ensure the safety of patients.