氟喹诺酮类药物不良反应调查及临床合理用药的分析

Analysis of Adverse Reaction of Fluoroquinolones Investigation and Clinical Rational Drug Use

目的调查分析氟喹诺酮类药物(FQNS)不良反应(ADR)情况及特点,为临床合理用药提供依据。方法回顾性分析我院2010年1月至2013年9月间53例应用氟喹诺酮类药物发生不良反应患者的临床资料,对引起不良反应发生的药物名称、给药途径、累及系统的分布及临床表现进行整理统计。结果本次调查中药物不良反应共涉及6种药品,其中左氧氟沙星所致不良反应所占的比例最大,为35.8%,静脉滴注氟喹诺酮类药物所致的不良反应所占比例最高,为52.8%,静脉注射所占的比例最低,为13.28%,不良反应累及神经系统所占的比例最高,占39.6%。结论临床使用氟喹诺酮类药物时应严格掌握用药适应证和给药方法,加强对不良反应的监测,以降低不良反应的发生。

ObjectiveTo investigate and analyze the lfuoroquinolones（FQNS）adverse reaction （ADR）and its characteristics, provide the basis for clinical rational drug use.MethodsA retrospective analysis of the clinical data of our hospital from 2010 January to 2013 September 53 cases of application of fluoroquinolones adverse reactions occurred in patients with, to cause adverse drug reaction name, route of administration, involving the system of distribution and clinical manifestations of statistics.ResultsThis investigation in drug adverse reaction involving a total of 6 kinds of drugs, for which the adverse effects of the largest proportion, 35.8%, adverse reaction of intravenous infusion of lfuoroquinolone induced the highest proportion, 52.8%, the lowest proportion of intravenous injection, 13.28%, adverse reactions involving the nervous system the highest proportion, accounting for 39.6%.ConclusionThe clinical use of lfuoroquinolones should be strictly controlled drug indications and methods of administration, strengthen the monitoring of adverse reactions occur, in order to reduce the adverse reaction.