某地区1021例维吾尔族非综合征唇腭裂流行病学的调查分析

Epidemiological Analysis of 1021 Cases of Non-syndromic Cleft Lip with or Without Cleft Plate with Uygur in A Area

目的：分析喀什地区维吾尔族先天性唇腭裂的发病情况与特点，探讨与唇腭裂发生有关的影响因素。方法对2001年--2012年间由微笑列车行动资助的1021例先天性唇腭裂患者进行回顾性临床分析。结果唇裂588例，唇裂伴腭裂293例，单纯腭裂140例，男性多于女性，比例1.3∶1。在单侧唇裂伴或完全性腭裂中，左侧与右侧相等1∶1有家族遗传史85例，占总数8.3%。母亲妊娠前3个月经历危险因素877例，占总数86%，近亲结婚124例，占12%，来自农村928例，占91%。结论唇腭裂发生与胚胎早期发育受环境因素、药物因素、遗传、营养等多因素有关。

ObjectiveTo analyze incidence and characteristics of congenital cleft lip and palate of Uyghur in Kashi area , and explore the inlfuencing factors associated with cleft lip and palate occurrence.Methods1021 cases of congenital cleft lip and palate patients were carried out retrospective clinical analysis, which funded by the smile train action on 2001-2012.Results588 cases of cleft lip, 293 cases of cleft lip and cleft palate, 140 cases of cleft palate, more men than women, ratio 1.3∶1. In unilateral cleft lip or complete cleft palate, left and right side are equal 1∶1, 85 cases have family genetic history, total 8.3%. 877 cases of mothers before 3 months pregnancy experiencing risk factors, accounting for 86%. Intermarriage of 124 cases, accounting for 12%. 928 cases from rural areas, accounting for 91%.ConclusionsOccurrence of cleft lip and palate and early embryonic development related to environmental factors, drug factors, genetic, nutritional and other factors.