摘要
目的:探讨15.羟基前列腺素脱氢酶(15-PGDH)在食管癌中的表达及其与临床病理特征的关系,并初步评价其意义,方法:随机收集66例食管癌手术病人的癌组织及相应癌旁正常组织,应用免疫组织化学检测15-PGDH表达,进一步分析其表达与食管癌临床病理的相关性.结果:与癌旁正常组织相比,食管癌中15-PGDH的表达水平显著降低甚至缺失.进一步统计分析显示,15-PGDH表达下调与食管癌的TNM分期、分化程度和是否有淋巴结转移密切相关.结论:食管癌中15.PGDH的表达减少或缺失参与了食管癌的发生发展过程,其可以作为反映食管癌恶性生物学行为的一个重要指标.
AIM: To investigate the expression and clinical significance of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) protein in esophagus cancer. METHODS: Immunohistochemistry was used to detect the expression of 15-PGDH protein in 66 esophagus cancer tissues and adjacent non-tumor tissues. Statistic analyses were explored to value its relation with the clinicopathological parameters. RESULTS: 15-PGDH expression was found decreased or even absent in esophagus cancer tissues compared with the corresponding non-tumor tissues. Further analysis about its relationship with clinicopathological parameters revealed that the downregulated of 15-PGDH was significantly related with differentiation grade, TNM stage and lymph node metastasis. CON- CLUSION: The expression of 15-PGDH is decreased or even absent in esophagus cancer tissues. The results suggest that 15-PG- DH may be an important indicator in carcinogenesis and progression of esophagus cancer.
出处
《转化医学电子杂志》
2014年第3期7-9,共3页
E-Journal of Translational Medicine
关键词
食管癌
15-羟基前列腺素脱氢酶
临床病理特征
esophagus cancer
15-hydroxyprostaglandin dehydrogenase (15-PGDH)
clinical pathologic parameters