15-PGDH在食管癌中的表达特征及临床意义

Expression and clinical significance of 15- hydroxyprostaglandin dehydrogenase in esophagus cancer

目的：探讨15．羟基前列腺素脱氢酶（15-PGDH）在食管癌中的表达及其与临床病理特征的关系，并初步评价其意义，方法：随机收集66例食管癌手术病人的癌组织及相应癌旁正常组织，应用免疫组织化学检测15-PGDH表达，进一步分析其表达与食管癌临床病理的相关性．结果：与癌旁正常组织相比，食管癌中15-PGDH的表达水平显著降低甚至缺失．进一步统计分析显示，15-PGDH表达下调与食管癌的TNM分期、分化程度和是否有淋巴结转移密切相关．结论：食管癌中15．PGDH的表达减少或缺失参与了食管癌的发生发展过程，其可以作为反映食管癌恶性生物学行为的一个重要指标．

AIM： To investigate the expression and clinical significance of 15-hydroxyprostaglandin dehydrogenase （15-PGDH） protein in esophagus cancer. METHODS： Immunohistochemistry was used to detect the expression of 15-PGDH protein in 66 esophagus cancer tissues and adjacent non-tumor tissues. Statistic analyses were explored to value its relation with the clinicopathological parameters. RESULTS： 15-PGDH expression was found decreased or even absent in esophagus cancer tissues compared with the corresponding non-tumor tissues. Further analysis about its relationship with clinicopathological parameters revealed that the downregulated of 15-PGDH was significantly related with differentiation grade, TNM stage and lymph node metastasis. CON- CLUSION： The expression of 15-PGDH is decreased or even absent in esophagus cancer tissues. The results suggest that 15-PG- DH may be an important indicator in carcinogenesis and progression of esophagus cancer.