输注不同容量胶体（万汶）对腰硬联合麻醉下剖宫产产妇循环功能的影响

Impact of ingesting different capacities of Wanwen on maternity circulation under the combined spinal and epidural anesthesia for caesarean section

目的：评价预充新一代中分子羟乙基淀粉（万汶）对腰硬联合麻醉下剖宫产产妇在手术过程中的循环功能造成的影响．方法：随机选取我院2012／9-2013／10入院接受剖宫产手术的产妇120例，随机分成A、B、C组，每组40例患者．入室开放上肢静脉即分别预充羟乙基淀粉130／0．4（万汶）2．5mL／kg、5mL／kg、10mL／kg扩容，在30min内完成，观察患者麻醉前后各时点的心率及血压变化情况．结果：血压和心率效果B组优于A组，C组优于A组，差异显著（P〈0．05），具有统计学意义．c组和B组差异无统计学意义．黄碱的平均需求量三组差异具有统计学意义．结论：预充万汶能够有效改善在腰硬联合麻醉下剖宫产产妇的血液循环功能，降低患者低血压出现的概率．

AIM： To assess the impact of filling a new generation of hydroxy ethyl starch molecules, named Wanwen, on maternity circulation under the combined spinal and epidural anesthesia for cesarean delivery in the operation process. METHODS： 120 cases of Caesarean patients admitted into our hospital from September 2012 to October 2013 were enrolled into this study. They are randomly divided into three groups： Group A, Group B and Group C, 40 cases in each group. Before starting the anesthesia, respectively input Wanwen＇s lactate solution 2. 5 mL/kg, 5.0 mL/kg and 10.0 mL/kg within half an hour. The heart rate and blood pressure changes in all the cases were observed before and after anesthesia. RESULTS： The blood pressure and heart rate of Group B and Group C were better than that of Group A, with statistical significance （P 〈 0.05）. Meanwhile, there was no statistical significance between Group B and Group C. For the heart function and the demand of ephedrine, the average difference between the three groups has statistical significance. CONCLUSION： Prefilling Wanwen can effectively improve the combined spinal and epidural anesthesia for cesarean section in the process of maternal blood circulation function, and reduce the probability of low blood pressure appearance in patients.