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凋亡抑制因子Survivin的研究进展 被引量：6

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摘要 Survivin是凋亡抑制因子家族的新成员，是迄今发现的最强大的凋亡抑制因子。Survivin兼有调节细胞周期和抑制细胞凋亡的双重作用，对细胞存活至关重要；Survivin在正常组织和肿瘤组织中的差异性表达，能准确反映肿瘤分级、淋巴转移、放化疗的疗效、复发倾向及预后。
作者 卢浩 刘士维 张伟
机构地区 吉林大学口腔医院
出处 《山东医药》 CAS 2014年第21期100-101,共2页 Shandong Medical Journal
关键词 SURVIVIN 凋亡抑制因子 差异性表达 细胞凋亡 细胞周期 细胞存活 肿瘤组织 正常组织
分类号 R34 [医药卫生—基础医学]
  • 相关文献

参考文献19

  • 1Li F, Ling X. Survivin study: An update of " What is the next wave" [J]. Cellular Physiol, 2006,208(3) :476-486.
  • 2Chantalat L, Skoufias DA, Kleman JP, et al. Crystal structure of human surviving reveals a bow tie-shaped dimer with two unusual alpha-helical extensions [ J ]. Mol Cell, 2000,6 ( 1 ) : 183-189.
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二级参考文献26

  • 1Karatzas T,Vasileiadis I,Kapetanakis S. Risk factors contributing to the difference in prognosis for papillary versus micropapillary thyroid carcinoma[J].{H}AMERICAN JOURNAL OF SURGERY,2013.
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  • 5Kim YA,Chang M,Park YJ. Detection of survivin and COX-2 in thyroid carcinoma:anaplastic carcinoma shows overexpression of nuclear survivin and low COX-2expression[J].KoreanJPathol,2012,(1):5560.
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  • 8Necochea-CampionRD,Chen CS,Mirshahidi S. Clinico-pathologic relevance of Survivin splice variant expression in cancer[J].{H}CANCER LETTERS,2013.
  • 9G(o)rgün D,Se(c)ik F,Midilli K. Diagnostic and prognostic significance of survivin levels in malignant pleural effusion[J].{H}Respiratory Medicine,2013,(8):1260-1265.
  • 10Chen Z,Liu N,Zhu G. Targeting of the antiapoptotic gene survivin in human thyroid carcinoma[J].Int J MolMed,2012,(3):465-472.

共引文献9

同被引文献59

  • 1江斌,菅志远,兰明银,严斌,曾少波.Survivin在胆囊癌组织中的表达及与病理的关系[J].中华实验外科杂志,2004,21(10):1204-1205. 被引量：5
  • 2Hai-GangLi,De-RongXie,Xi-MingShen,Hong-HaoLi,HongZeng,Yun-JieZeng.Clinicopathological significance of expression of paxillin, syndecan-1 and EMMPRIN in hepatocellular carcinoma[J].World Journal of Gastroenterology,2005,11(10):1445-1451. 被引量：38
  • 3万云乐,丁伟,郑树森,闵军,王捷.原发性胆囊癌Survivin和Ki-67的表达及意义[J].中华实验外科杂志,2006,23(8):919-921. 被引量：17
  • 4鲜军舫,王振常,罗德红,等.头颈部影像学诊断必读[M].北京:人民军医出版社,2007:197-199.
  • 5Davis TW, O'Neal JM,Pagel MD,et al. Synergy between celecoxib and radiotherapy results from inhibition of cy- clooxygenase-2-derived prostaglandin E2,a survival fac- tor for tumor and associated vasculature[J]. Cancer Res, 2004,64( 1 ) : 279-285.
  • 6Milas k Cyclooxygenase-2 (COX-2) enzyme inhibitors and radiotherapy: Preclinical basis[J]. Am J Clin 0neol,2003, 26(4) :66-69.
  • 7Bai XM ,Jiang H, Ding JX, et al. Prostaglandin E2 upreg- ulates survivin expression via the EP1 receptor in hepa- tocellular carcinoma cells[J]. Life Sciences,2010, (86): 214-223.
  • 8Adegbola O,Pasternack GM.Phosphorylated retinoblastoma protein complexes with pp32 and inhibits pp32-mediated apoptosis[J].J Biol Chem,2005,280(16):15497-15502.
  • 9Xu C,Yamamoto-Ibusuki M,Yamamoto Y,et al.High survivin m RNA expression is a predictor of poor prognosis in breast cancer:a comparative study at the m RNA and protein level[J].Breast Cancer,2014,21(4):482-490.
  • 10Antonatopoulou AG,Floratou K,Bravou V,et al.The survivin-31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival[J].Anal Cell Pathol(AMST),2010,33(5):177-189.

引证文献6

二级引证文献14

山东医药
2014年 第21期

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