DNA甲基化和非编码RNA在肝细胞癌转移复发中的研究进展

Research progress of DNA methylation and non-coding RNA in the metastasis and recurrence of hepatocellular carcinoma

转移和复发是影响肝细胞癌(肝癌)患者生存的主要因素,目前,肝癌的复发转移机制取得了一些进展,表观遗传学调控在DNA甲基化/羟甲基化修饰、组蛋白修饰、染色质重塑及非编码RNA表达等方面起重要作用,其中DNA甲基化和非编码RNA在肝癌转移复发中的作用研究较多,笔者简要综述DNA甲基化和非编码RNA在肝癌转移复发中的研究进展。

Objective： Metastasis and recurrence are the main factors affecting the survival of patients with hepatocellular carcinoma（liver cancer）, at present, rhe mechanism of hepatocellular carcinoma recurrence and metastasis have gotten some progress. The epigenetic regulation plays an important role in DNA methylation / hydroxyl methylation, histone modification, chromatin remodeling and expression of non-coding RNA etc.,among them, the researchers pay more attention on how DNA methylation and non-coding RNA to affect the liver cancer metastasis and recurrence. The author reviews DNA methylation and non-coding RNA in the recurrence and metastasis of liver cancer research progress.