乙型肝炎病人病程变化对血清中T_3、T_4水平影响及其临床意义

Clinical significance and influence of changes of serum triiodothyronine and thyroxine levels on the different course of hepatitis B patients

目的:对不同病程的乙型肝炎病人进行甲状腺激素水平的测定,重点研究T3、T4与其相关性,揭示其临床意义。方法:选取96例不同病程的乙型肝炎患者采用化学发光法测定其甲状腺激素水平。结果:通过实验发现慢性乙肝时肝细胞损害相对较轻,对血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)水平影响不明显;乙肝后肝硬化、重症肝炎时肝细胞损害严重,病人的血清三碘甲状腺原氨酸水平明显下降,甲状腺素轻度下降或正常,并且肝脏细胞损害越严重血清三碘甲状腺原氨酸(T3)下降越明显。结论:血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)水平尤其是血清三碘甲状腺原氨酸(T3)水平可作为评估乙肝病情、肝脏损害程度及预后的一项重要指标。

Objective：To observe changes of serum triiodothyronine and thyroxine levels on the different course of hepatitis B patients in order to explore the correlation with T3 and T4 ,to reveal its clinical significance. Methods： The serum thyroid hormone levels were monitored in 96 cases on the different course of hepatitis B patients by chemiluminescence. Results： Liver cell damage was relatively light in which the serum T3、T4 level don’t not obviously changed in chronic hepatitis B patients. Serious damage to the liver cells, the serum T3 levels were significantly decreased, T4 lightly decreased or normal, and the more severe liver cell damaged the more obvious T3 decreased in hepatitis B patients with cirrhosis and severe hepatitis B patients. Conclusion： The serum T3,T4 levels, particularly serum levels of T3 can assess the extent of hepatitis B disease, or be an important indicator of liver function after recovery.