南京市城区部分居民血清维生素D水平评估

Vitamin D status of Nanjing urban residents

目的：了解南京市居民血清维生素D水平，为骨质疏松防治提供依据。方法2011年6月至11月招募南京市城区≥40岁居民2786名，其中40～49岁490人（17.6％），50～59岁1084人（38.9％），60～69岁912人（32.7％），70～78岁300人（10.8％）。采集受试者清晨空腹静脉血，应用酶联免疫法测定血清25-羟维生素D [25OHD]浓度。以血清25OHD≥50 nmol/L和≥75 nmol/L分别定义为维生素D正常及良好，以血清25OHD＜25 nmol/L定义为维生素D缺乏，评估南京城区居民血清维生素D水平。采用超声骨密度仪（QUS），用超声振幅衰减（BUA）值及超声声速（SOS）值推算骨密度（BMD）。结果南京城区部分居民血清25OHD平均水平为（44.71±14.68） nmol/L，维生素D正常及良好者分别占31.7％和2.5％。40～49岁组血清25OHD平均为（43.48±14.23） nmol/L，50～59岁组为（45.33±14.49） nmol/L，60～69岁组为（44.41±14.66） nmol/L，70～78岁组为（45.36±15.97） nmol/L，4组间比较差异无统计学意义。血清25OHD缺乏者男性占4.3％（45例），女性占6.7％（117例），差异有统计学意义（P＜0.05）；受试者BMD水平平均为（0.491±0.112） g/cm^2， BMD和血清25OHD浓度呈正相关，差异有统计学意义（r＝0.038， P＝0.047）。结论南京市部分居民普遍存在维生素D缺乏，女性维生素D水平低于男性。

Objective To assess vitamin D status in Nanjing urban residents by two kinds of standards . Methods A total of 2786 adults aged 40 years or older in Nanjing urban area were enrolled in this cross-sectional study from June to December 2011.490 （17.6%） of them were between 40-49 years, 1084 （38.9%） between 50-59 years, 912 （32.7%） between 60-69 years, and 300 （10.8%） between 70 -78 years.Serum 25OHD level was tested using ELISA.We assessed the vitamin D status of the residents by two different standards of classification .Calcaneal QUS was evaluated by BUA （ dB/MHz ） and SOS （ m/s ） by a Sahara device; T-score were calculated from BUA and SOS.Results The average serum 25OHD level was （44.71 ±14.68 nmol/L）;if defining serum 25OHD≥50 nmol/L, ≥75 nmol/L as vitamin D adequate, there were 31.7%and 2.5%subjects with vit D adequuae; the se-rum 25OHD concentration of the 40 -49 age group was 43.48 ±14.23 nmol/L and 50-59, 60 -69, 70-78 age group was 45.33 ±14.49 nmol/L, 44.41 ±14.66 nmol/L, 45.36 ±15.97 nmol/L respectively, and there was no statistical difference among the four age groups.The percent of serum 25OHD deficient （ defined as serum 25OHD 〈25 nmol/L） among men was 4.3%, 6.7 % among women （ P 〈0.05 ） .The average BMD level was （ 0.491 ±0.112） g/cm^2; the BMD level and serum 25OHD concentration were positively correlated.Conclusion The prevalence of vitamin D insufficiency or deficieny of Nanjing urban residents was common , the level of vitamin D in women were lower than that of men .