双膦酸盐可能降低死亡率

Effects of bisphosphates on reduced mortality risk

自1969年首次全面报道双膦酸盐的生理作用至今已逾40余年。作为最有效的抗骨吸收药物之一,双膦酸盐在防治骨质疏松以及肿瘤相关骨骼并发症方面的作用广为人知。近年研究表明,双膦酸盐可能具有直接降低人群死亡率的作用。除与双膦酸盐降低骨折发生率的作用相关外,可能还与双膦酸盐具有促进机体生理功能恢复、延缓机体衰老、降低心血管事件风险程度和抗肿瘤的作用有关。另外,对肿瘤人群的研究提示双膦酸盐具有提高生存率、延长肿瘤人群生存期限的作用。上述研究结果拓展了双膦酸盐的临床应用价值。如何进一步验证这些结果并将其更好地应用于临床,可能是未来的一个研究热点。

It has been more than 40 years since the first full publications on the biological effects of the bisphosphonates , appeared in 1969 .Bisphosphonates are the leading drugs used to treat osteoporosis and skeletal complications associated with tumors , especially multiple myeloma and bone metastases .Interestingly , recent studies showed that bisphosphonate , may have the direct effect on reduced mortality risk .The underlying mechanisms may be the effects of bisphosphonates on preventing fracture , improving physiological resilience , preventing frailty , reducing risks of cardiovascular events, or anti-tumor.Furthermore, studies in population with tumors （ e.g., multiple myeloma, colon cancer ） showed that patients treating with bisphosphonate had higher survival rate and longer overall survival duration than patients taking placebo .All of these results show us a new perspective of bisphosphonate in clinical application .How to further prove these results will be our next important step .