多项肿瘤标志物检测在老年前列腺肿瘤患者中的诊断价值

The value of multiple tumor markers detection in diagnosis of prostate cancer in elderly patients

目的探讨多项肿瘤标志物检测对老年前列腺肿瘤患者的诊断效果与应用价值。方法选取2012年2月至2014年2月间收治的60例老年前列腺肿瘤患者作为观察组,以同期收治的60例前列腺良性病变老年患者作为对照A组,100例健康老年人作为对照B组,采用酶联免疫法检测癌胚抗原、前列腺特异抗原、前列腺特异膜抗原及前列腺特异性酸性磷酸酶的水平,分析各种标志物的诊断价值。结果观察组患者前列腺特异抗原为(5.27±0.43)μg/L,前列腺特异膜抗原为(28.91±4.19)μg/L,前列腺特异性酸性磷酸酶为(16.65±3.98)μg/L,癌胚抗原为(7.56±4.37)μg/L,均显著高于对照A组和对照B组,差异有统计学意义(P<0.05)。观察组患者前列腺特异抗原阳性率为96.7%,前例腺特异膜抗原阳性率为98.3%,前列腺特异性酸性磷酸酶阳性率为96.7%,癌胚抗原阳性率为93.3%,均显著高于对照A组和对照B组,差异有统计学意义(P<0.05)。结论多项肿瘤标志物联合检测具有较好的敏感性与特异性,可明确表现患者病变性质,同时可通过联合检测对预后进行评估,提高临床治疗效果,延长患者生存时间,具有确切的应用价值。

Objective To investigate the clinical detection of tumor markers to carry out a number of diagnostic results and value for prostate cancer in elderly patients. Methods 60 cases of prostate cancer in elderly patients in our hospital from February 2012 to February 2014 were selected as the observation group, while 60 cases of benign prostatic elderly patients admitted to the same period as the control group A, 100 cases of healthy elderly as control group B, respectively, the use of enzyme-linked immunosorbent assay analysis of carcinoembryonic antigen, prostate specific antigen, prostate-specific membrane antigen and prostate-specific acid phosphatase levels, analyze the diagnostic value of various markers. Results The results of precedent gland -specific antigen was observed in patients （5.27 ± 0. 43 ） μg / L, the result of prostate specific membrane antigen （28.91 ± 4. 19） μg/ L, prostate-specific acid phosphatase results （16. 65 ±3.98） μg/ L, carcinoembryonic antigen （7.56 ± 4. 37） μg/ L, were significantly higher than the other two groups, the difference were statistically significant （ P 〈 0. 05 ） ; Positive rate in observation group patients prostate specific antigen was 96.7% , specificity of membrane gland precedent antigenpositive rate of 98.3% , prostate-specific acid phosphatase -positive rate of 96. 7%, careinoembryonic antigen positive rate of 93.3%, which was significantly better than the other two groups was statistically significant （P 〈 0. 05）. Conclusion The number of combined detection of tumor markers has better sensitivity and specificity, patients can clearly demonstrate the nature of the lesion, and can assess the effect on prognosis through joint testing, the effect of improving the clinical treatment and prolong survival of patients with the exact value.