卵巢局部IGF-I系统与多囊卵巢综合征胰岛素抵抗的相关性研究被引量：4

Study of the relationship between the IGF-I system in ovary and the polycystic ovary syndrome combined with insulin resistance

原文传递

导出

摘要目的:研究卵巢局部胰岛素样生长因子-I系统(IGF-I系统)在伴有胰岛素抵抗多囊卵巢综合征中的作用机制。方法选择30例合并胰岛素抵抗的PCOS(polycystic ovary syndrome)患者为试验组,30例患有卵巢良性肿瘤需手术探查的患者为对照组。检测并对比血清、小卵泡液中IGF-I、胰岛素样生长因子结合球蛋白-1(IGFBP-1)与各项性激素,FI,2hI,ISI,QUICK I,卵巢超声指标,研究其与各种指标间的相关性。结果试验组小卵泡液IGF-I高于对照组(P<0.01),小卵泡液及血清IGFBP-1低于对照组(P<0.05,P<0.01)。试验组小卵泡液IGF-I水平高于血清(P<0.01),小卵泡液IGFBP-1水平低于血清(P<0.05)。试验组小卵泡液IGF-I与T0、E2及卵巢体积(OV),卵巢总面积(TA),卵泡数(FN),空腹胰岛素(FI),服糖后2h胰岛素(2hI)呈正相关(P<0.05);血清IGF-I与胰岛素敏感指数(ISI),体重指数(BMI),腰臀比(WHR)呈正相关(P<0.05),与定量胰岛素敏感指数(QUICK I)呈负相关(P<0.05);试验组小卵泡液及血清IGFBP-1与FI,2hI呈负相关(P<0.05)。结论 IR可能通过影响卵巢局部IGF-I系统,刺激卵巢分泌雄激素,引发排卵障碍,在PCOS的发病机制中起到重要作用。 Objective：To study effects of ovarian insulin-like growth factor-I（IGF-I）system on PCOS with insulin resistance（IR）. Methods：30 insulin-resistant PCOS patients and 30 patients with gynecology benign disease were enrolled. IGF-I and insulin-like growth factor binding protein-1（IGFBP-1）in follicular fluid and serum,reproductive hormones,insulin sensitivity indexs,ovarian ultrasound parameters were measured and compared between two groups.Correlation of IGF-I system with other parameters were analysed. Results：Follicular fluid IGF-I in PCOS group was significantly lower than in control group（P0.01）. Both serum and follicular fluid level of IGFBP-1 in PCOS group were all markedly lower than in control group（P0.05,P0.01）. In PCOS group,IGF-I in follicular fluid was significantly higher than in serum（P0.01）,and IGFBP-1 in follicular fluid was significantly lower than in serum（P0.05）.In PCOS group,follicular fluid IGF-I positively correlated with T0,E2,ovary volume（OV）,total area（TA）,follicle number（FN）,free insulin（FI）,2hI（P0.05）. Serum IGF-I positively correlated with insulin sensitivity index（ISI）,body mass index（BMI）,waist/hip ratio（WHR）（P0.05）,negatively correlated with QUICK I（P0.05）.Both follicular fluid and serum IGFBP-1 negatively correlated with FINS,2hI（P0.05）. Conclusion：These results raise the possibility that IR likely contributes to hyperandrogenism and anovulatiaon in PCOS by effecting ovarian IGF-I system.

作者李晓林毕淑娜孙颖孙宝治范俊孟莉袁文娟

机构地区青岛大学医学院附属青岛市市立医院东院区妇科山东省青岛市市南区妇幼保健所山东省青岛市第五人民医院妇科

出处《中国优生与遗传杂志》 2014年第6期17-19,61,F0002,共5页 Chinese Journal of Birth Health & Heredity

关键词多囊卵巢综合征胰岛素抵抗胰岛素样生长因子-I 胰岛素样生长因子结合球蛋白-1 Polycystic ovary syndrome （PCOS） Insulin resistance （IR） Insulin-like Growth Factor I （IGF-I）Insulin-like Growth Factor Binding Protein-1 （IGFBP-1）

分类号 R711.75 [医药卫生—妇产科学]

引文网络
相关文献

参考文献9

1Amato G, Izzo A, Tucker A, et al. Insulin-like growth factor binding protein-3 reduction in follicular fluid in spontaneous and stimulated cycles[J]. Fertil Steril, 1998, 70:141-144.
2Velazquez MA , Hadeler KG , Herrmann D, et al. In vivo oocyte IGF-1 priming increases inner cell mass proliferation of in vitro- formed bovine blastocysts[J]. Theriogenology, 2012, 78: 517-527.
3Arrnstronn DG, McEvoy TG, Baxter G, et al. Effect of dietary energy and protein on bovine follicular dynamics and embryo Production in vitro :associations with the ovarian insulin like Growth factor system[J]. Biol Reprod, 2001,64 :566-1574.
4Nexon AJ, Brower-Toland BD, Sandell LJ. Primary nucleotide structure of predominant and alternate splice forms of equine insulin-like growth factor I and their gene expression patterns in tissues [J]. Am J Vet Res, 1999, 60:1234-1241.
5Schoyer KD, Liu HC, Witldn S, et al. Serum insulin-like growth factor Ⅰ (IGF-Ⅰ)and IGF-binding protein 3 (IGFBP-3)in IVF patients with polycystic ovary syndrome :correlations with outcome[J]. Fertility and Sterility, 2007, 88:139-144.
6Kwon H, Choi DH, Bae JH, et al. mRNA expression pattern of insulin-like growth factor components of granulosa cells and cumulus cells in women with and without polycystic ovary syndrome according to oocyte maturity[J]. Fertility and Sterility, 2010,94:2417-2420.
7Mayama R, Izawa T, Sakai K, et al. Improvement of insulin sensitivity promotes extravillous trophoblast cell migration stimulated by insulin-like growth factor-Ⅰ[J].Endocr J, 2013,60( 3 ): 359-68.
8Velazquez MA, Hermann D, Kues WA , et al. Increased apoptosis in bovine blastocysts exposed to high levels of IGF1 is not associated with downregulation of the IGF1 receptor[J]. Reproduction, 2011,141:91-103.
9Lungu AO, Zadeh ES, Goodling A, et al. Insulin resistance is a sufficient basis for hyperandrogenism in lipodystrophic women with polycystic ovarian syndrome[J]. The Journal of Clinical Endocrinology and Metabolism, 2012, 97:563-567.