老年女性类风湿关节炎合并骨质疏松症的代谢特点分析

Analysis of Metabolic Characteristics in Elderly Women with Rheumatoid Arthritis Combined Osteoporosis

目的:探讨老年女性类风湿关节炎(RA)合并骨质疏松症的代谢特点。方法:选择老年绝经后女性RA患者共59例,检测患者血生化代谢指标如血糖、血脂、CRP等和骨代谢指标如骨钙素(OC)、β-胶原特殊序列(β-Crosslaps)甲状旁腺素(iPTH)等,并进行统计分析。结果:骨质疏松患者的绝经时间、病程长度、OC、β-Crosslaps、iPTH显著高于骨量正常和骨量减少的患者,25羟基维生素D显著低于骨量正常和骨量减少的患者(P均<0.05)。RA患者的骨密度水平与是否使用激素和X线分期情况无关。结论:老年女性RA患者易发生骨质疏松,出现骨质疏松的RA女性患者绝经时间更长,可出现脂代谢紊乱及明显的维生素D缺乏,并具有高转换型骨代谢特点。

Objective： To investigate the metabolic characteristics of older women with rheumatoid arthritis combined osteoporosis. Methods： 59 older postmenopausal women patients with RA were selected. The blood biochemical metabolism indexes of patients such as the blood glucose, the blood lipid and the CRP were detected and the bone metabolic indices such as osteocalcin （OC）, beta collagen special sequence （beta Crosslaps） parathyroid hormone （iPTH） were analyzed statistically. Results： Postmenopausal time, the course length, OC, 13-Crosslaps, iPTH levels in RA patients with osteoporosis were significantly higher than those of the patients with normal bone mass and loss of bone mass, but 25-hydroxyvitamin D were significantly lower than normal bone mass and loss of bone mass in patients （P〈0.05）. Bone mineral density in RA patients has nothing to do with whether or not using hormones and the X-ray installments. Conclusion： Aged RA women were prone to have osteoporosis, longer postmenopausal time in osteoporosis, lipid metabolism disorders and vitamin D deficiency, thus have a high turnover of bone metabolic characteristics.