TGF-β1、HIF-1α、VEGF在胃癌组织及癌旁组织中的表达及临床意义

Expression and Clinical Significance of TGF-β1, HIF-1α, VEGF in Gastric Cancer Tissues and Corresponding Adjacent Noncancerous Tissues

目的:研究TGF-β1(转化生长因子-β1)、HIF-1α(低氧诱导因子-1α)、VEGF(血管内皮生长因子)在胃癌组织及癌旁组织中的表达及临床意义。方法:选取于我院就诊的160例胃癌手术患者切除的组织,采用免疫组化技术检测手术切除的胃癌组织中的TGF-β1、HIF-1α及VEGF的表达,分析其与患者临床病理参数的关系。结果:免疫组化结果显示:TGF-β1、HIF-1α及VEGF在胃癌组织中的表达均高于癌旁组织,差异均有统计学意义(P<0.05);TGF-β1、HIF-1α及VEGF的表达均与肿瘤分期、淋巴结转移及浸润深度有关(P<0.05);VEGF的表达分别与TGF-β1、HIF-1α的表达呈相关关系(P<0.05)。结论:TGF-β1、HIF-1α及VEGF在胃癌组织中的表达与胃癌的病理学特征有关,检测TGF-β1、HIF-1α及VEGF的表达将有助于临床诊治胃癌患者。

Objective： To study the expression of TGF-β1（Transforming growth factor-β1）, HIF-1α（Hypoxia-inducible factor-1α）, VEGF（Vascular endothelial growth factor） and their clinical significance in gastric cancer tissues and corresponding adjacent noncancerous tissues. Method： 160 cases of gastric carcinoma tissues were chosen to detect the expression of TGF-β1, HIF-1α and VEGF in gastric carcinoma tissues which had been removed by the immunohistochemistry technology. The relationship between the expression and the clinical pathological parameters of patients were analyzed. Results： Immunohistochemistry showed： The expression of TGF-β1,HIF-1α, VEGF in gastric carcinoma tissues was higher than in corresponding adjacent noncancerous tissues, the differences were all statistically significant（P〈0.05）; the expression of TGF-β1, HIF-1α, VEGF was all related with neoplasm staging, lymphatic metastasis and infiltration depth（P〈0.05）. The expression of VEGF were related with the expression of TGF-β1 and HIF-1α（P〈0.05）. Conclusion： The expression of TGF-β1, HIF-1α, VEGF in gastric carcinoma tissues were correlated with the pathological features of gastric carcinoma, detecting the expression of TGF-β1, HIF-1α, VEGF will be helpful to clinical diagnosis and treatment of patients with gastric carcinoma.