摘要
目的:研究TGF-β1(转化生长因子-β1)、HIF-1α(低氧诱导因子-1α)、VEGF(血管内皮生长因子)在胃癌组织及癌旁组织中的表达及临床意义。方法:选取于我院就诊的160例胃癌手术患者切除的组织,采用免疫组化技术检测手术切除的胃癌组织中的TGF-β1、HIF-1α及VEGF的表达,分析其与患者临床病理参数的关系。结果:免疫组化结果显示:TGF-β1、HIF-1α及VEGF在胃癌组织中的表达均高于癌旁组织,差异均有统计学意义(P<0.05);TGF-β1、HIF-1α及VEGF的表达均与肿瘤分期、淋巴结转移及浸润深度有关(P<0.05);VEGF的表达分别与TGF-β1、HIF-1α的表达呈相关关系(P<0.05)。结论:TGF-β1、HIF-1α及VEGF在胃癌组织中的表达与胃癌的病理学特征有关,检测TGF-β1、HIF-1α及VEGF的表达将有助于临床诊治胃癌患者。
Objective: To study the expression of TGF-β1(Transforming growth factor-β1), HIF-1α(Hypoxia-inducible factor-1α), VEGF(Vascular endothelial growth factor) and their clinical significance in gastric cancer tissues and corresponding adjacent noncancerous tissues. Method: 160 cases of gastric carcinoma tissues were chosen to detect the expression of TGF-β1, HIF-1α and VEGF in gastric carcinoma tissues which had been removed by the immunohistochemistry technology. The relationship between the expression and the clinical pathological parameters of patients were analyzed. Results: Immunohistochemistry showed: The expression of TGF-β1,HIF-1α, VEGF in gastric carcinoma tissues was higher than in corresponding adjacent noncancerous tissues, the differences were all statistically significant(P〈0.05); the expression of TGF-β1, HIF-1α, VEGF was all related with neoplasm staging, lymphatic metastasis and infiltration depth(P〈0.05). The expression of VEGF were related with the expression of TGF-β1 and HIF-1α(P〈0.05). Conclusion: The expression of TGF-β1, HIF-1α, VEGF in gastric carcinoma tissues were correlated with the pathological features of gastric carcinoma, detecting the expression of TGF-β1, HIF-1α, VEGF will be helpful to clinical diagnosis and treatment of patients with gastric carcinoma.
出处
《现代生物医学进展》
CAS
2014年第18期3524-3527,共4页
Progress in Modern Biomedicine