血清网膜素-1与绝经后女性冠心病的相关性

Omentin-1 Is Associated with Coronary Artery Disease in Postmenopausal Women

目的:网膜素是最近发现的脂肪因子,肥胖或2型糖尿病(diabetes mellitus,DM)患者血清网膜素-1较正常者明显降低。本次研究主要为观察绝经后女性血清网膜素-1水平与冠心病的相关性。方法:选取我院心内科住院有心绞痛症状,并行冠脉造影的105例绝经后女性患者。依据冠脉造影结果分为冠心病组(67例)和对照组例(3),常规收集临床资料,包括年龄、体重指数(body mass index,BMI)、吸烟史、高血压病史、糖尿病史及血液生化和血脂指标;酶联免疫吸附剂测定(enzyme linked immunosorbent assay,ELISA)法检测血清网膜素-1浓度。结果:冠心病组血清网膜素-1水平显著低于对照组(205.62±73.31 vs 401.64±146.79,P<0.001)。单因素logistic回归分析示吸烟、高血压病史、糖尿病史、高脂血症史、网膜素-1水平降低是冠心病组的独立危险因素(P<0.05)。多因素logistic回归分析示血清网膜素-1水平降低是冠心病组的独立危险因素(P<0.001)。结论:绝经后女性血清网膜素-1水平下降是冠心病的独立危险因素,可能可成为绝经后女性冠心病的预测指标。

Objective： Omentin-1 is a newly identified adipokine expressed mainly in visceraladipose tissue, with reportedly lower levels in patients with overweight or patients with obesity and in those with type 2 diabetes mellitus. We investigated whether serum omentin-1 levels were associated with coronary artery disease （CAD） among postrnenopausal women. Methods： We enrolled 105 postmenopausal women who had undergone coronary angiography for suspected angina, and they were divided into 2 groups based on the results of coronary angiography （CAD group and control group）. The age, body mass index, the history of hypertension, diabetes mellitus, hyperlipidemia, smoking and blood biochemical indicators were recorded. Omentin-1 levels were measured using ELISA methods. Results： Serum omentin levels decreased significantly in the CAD patients （ 205.62± 73.31 vs 401.64± 146.79, P〈0.001）. Several parameters were found to be significant in the univariate analysis, including the history of hypertension, diabetes mellitus, hyperlipidemia, smoking and omentin 1 level. Alter Multivariate Analyses for CAD, a decreased omentin-1 level was found to be an independent predictor of CAD. Conclusions： Our article indicates that a decreased omentin-1 level is associated with CAD among postmenopausal women.