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Appetite control: why we fail to stop eating even when we are full?

Appetite control: why we fail to stop eating even when we are full?
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摘要 We often eat more than our body needs. We live in an environment where high calorie food is abundant and physical activities are limited. Living in this environment, maintaining healthy bodyweight becomes challenging and obesity becomes a social burden. Why do we continue to eat even after the metabolic needs are satisfied? Feeding is an ancient behavior essential to survive. Thus the mechanisms to regulate appetite, energy expenditure, and energy storage are well conserved throughout animals. Based on this conservation, we study why we fail to control appetite using a simple genetic model system C. elegans. We have discovered certain genetic components that when misregulated have animals eat more and store more fat. In this review we discuss how these genes work in the appetite control circuit to ultimately understand overall appetite control behavior. We will also briefly discuss how social influence affects feeding regardless of the metabolic status of an animal. We often eat more than our body needs. We live in an environment where high calorie food is abundant and physical activities are limited. Living in this environment, maintaining healthy bodyweight becomes challenging and obesity becomes a social burden. Why do we continue to eat even after the metabolic needs are satisfied? Feeding is an ancient behavior essential to survive. Thus the mechanisms to regulate appetite, energy expenditure, and energy storage are well conserved throughout animals. Based on this conservation, we study why we fail to control appetite using a simple genetic model system C. elegans. We have discovered certain genetic components that when misregulated have animals eat more and store more fat. In this review we discuss how these genes work in the appetite control circuit to ultimately understand overall appetite control behavior. We will also briefly discuss how social influence affects feeding regardless of the metabolic status of an animal.
出处 《Frontiers in Biology》 CAS CSCD 2014年第3期169-174,共6页 生物学前沿(英文版)
关键词 CGMP TGFI3 C. elegans SATIETY APPETITE obesity cGMP, TGFI3, C. elegans, satiety, appetite, obesity
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  • 1Zhang M, Xia G, Zhou B, Wang C. Gonadotropin-eontrolled mammal oocyte meiotic resumption. Front Biosci, 2007,12:282--296.
  • 2Zhang M, Ouyang H, Xia G. The signal pathway of gonadotropins-induced mammalian oocyte meiotic resumption. Mol Human Reprod, 2009, 15:399-409.
  • 3Zhang Meijia, Su Youqiang, Sugiura Koji, Xia Guoliang, Eppig J J. Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes. Science, 2010, 330:366-369.

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