一锅法合成6-氯吲哚-2-酮

One-Pot Synthesis of 6-Chloro-2-Indolinone

改进了齐拉西酮的重要中间体6-氯吲哚-2-酮的合成方法,以4-氯-2-硝基甲苯为起始原料,一锅法完成缩合、水解、氧化脱羧、还原、环合反应,收达50%以上,产品纯度在98%以上,结构经1HNMR确认。

We Improved the synthesis method of 6-chloro-2-indolione, which is a important intermediate of ziprasidone. The compound was obtained by using 4-chloro-2- nitro toluene as the starting material, followed by condensation, hydrolysis, oxidation and decarboxylation, redution , cyclization in the water-carrying agent in one-pot. The yield of the product was more than 50 %, and the structure of the compound was characterised by1HNMR.