FLG基因及其突变与婴幼儿哮喘相关性研究进展

The Research Progress of FLG Gene and Assosiation Between Infant Asthma and FLG Gene Mutations

丝聚蛋白(FLG,filaggrin)基因是位于人类染色体1q21.3的一个基因,有多个突变位点,并突变点有明显的种族以及人群差异性。多项研究指出:FLG突变与鱼鳞病、特应性皮炎、过敏性鼻炎、哮喘等特应性疾病相关。哮喘(asthma)是儿科中最常见的慢性呼吸道疾病,并且哮喘的发病率和死亡率均有逐渐增加的趋势。近年来,哮喘的候选基因研究已经不断完善,FLG基因就是新发现的一个哮喘易感基因。通过对FLG基因与婴幼儿哮喘相关性的研究,可进一步认识哮喘的发病机制,并能为哮喘的早期诊断及早期干预提供新思路,为哮喘的基因诊断及治疗开辟新道路。

Filaggrin gene, located on human chromosome lq21.3, contents many mutations, which has abvious contrast in race and population. A number of researchs pointed out FLG mutations are correlated with atopic diseases, for example, ichthyosis vulgaris, atopic dermatitis, allergic thinitis and asthma. Asthma is the commonest disorder of chonic respiratory diseases in pediatics. Incidence and mortality of asthma is on the increase. In recent years, the research of asthma candidate genes is updated continuely. FLG gene is a new - found susceptible gene of asthma. Through the research on the assosiaton between FLG gene and infant asthma, can further understanding of asthmatic pathogenesis , can provide a new idea for early diagnosis and prevent of asthma, and open up a new way for gene diagnosis and treatment of asthma.