T波电交替临床研究进展

Clinical Research Progress T-wave alternans

研究表明,T波电交替(TWA)与心肌细胞复极的空间离散、心肌细胞动作电位的变化及离子通道的改变引起室性心律失常相关,已被公认为当前对心律失常事件最具预测价值的无创电生理检测指标。TWA可见于多种疾病,如冠状动脉粥样硬化性心脏病、心力衰竭、心律失常、休克及长QT间期综合征等。现结合文献对TWA的形成机制,检测方法,判定标准及临床应用研究进行综述。

Over decades, it has linked alternans of repolarization in cellular, whole - heart, and human studies with spatial dispersion of repolarization, alternans of cellular action potential, and fluctuations in ionic currents that may lead to ventricular arrhythmias. TWA has been recognized as the current most predictive value for arrhythmia events non - invasive electrophysiological detection index. It may discovered in many disease, such as coronary artery disease, heart failure, heart arrhythmia, shock, long QT syndrome and so on. We combined with literature on the formation mechanism of TWA, detection method, decision criteria and clinical application are reviewed in this.