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p53和MMP-2在肺癌组织中的表达及意义 被引量：1

Expressions of p53 and MMP-2 in Lung Cancer Tissues and Their Significances
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摘要 [目的]探讨p53及MMP-2蛋白在人肺癌组织中的表达情况。[方法]采用量子点免疫荧光组织化学(QDs-IHC)技术分析和研究人肺癌组织芯片中p53及MMP-2蛋白的表达情况,并检测p53及MMP-2蛋白在肺癌组织中的共表达。[结果]QDs-IHC检测分析显示,p53及MMP-2蛋白在肺癌组的表达均高于对照组,差异显著(P<0.05)。p53及MMP-2蛋白表达之间呈显著正相关(r=0.533,P<0.01)。[结论]新型半导体免疫荧光标记试剂—量子点结合组织芯片技术(QDs-IHC)可以检测到p53及MMP-2蛋白在肺癌组织中的表达,p53及MMP-2在肺癌组织中的共表达对肺癌的恶性进展起促进作用。 [Purpose ] To investigate the expression of p53 and MMP-2 in lung carcinoma tissues. [Methods ] Expression of p53 and MMP-2 in lung carcinoma tissues and normal lung tissues was detected by quantum dots combined with IHC technology （QDs-IHC）. [Results] Expressions of p53 and MMP-2 in lung carcinoma tissues was higher than those in control group （P〈0.05）. Expressions of p53 and MMP-2 in lung carcinoma showed a positive correlation （t=-0.533 ,P〈0.01）. [Conclusion] QDs-II-IC can be used to detect the expression of p53 and MMP-2. Expression of p53 and MMP-2 might play an important role in predicting the progress of lung carcinoma.
作者 张书卿 张绪良
机构地区 黄石市中心医院
出处 《肿瘤学杂志》 CAS 2014年第6期456-459,共4页 Journal of Chinese Oncology
关键词 量子点技术 肺肿瘤 P53 MMP-2 quantum dots lung neoplasms p53 MMP-2
分类号 R734.2 [医药卫生—肿瘤]
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参考文献10

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肿瘤学杂志
2014年 第6期

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