摘要
目的:优化5,7,3’,4’-O-四甲基槲皮素(TMQ)的制备工艺。方法:以5,7,3’,4’-O-四甲基芦丁为原料,采用单因素实验和正交试验对TMQ的制备工艺进行优化。结果:酸性水溶液法制备TMQ的最佳工艺条件为:乙醇浓度0,温度80℃,盐酸浓度0.50%,水解时间1.0 h。结论:该方法收率高、工艺简单、稳定可行。
This study was aimed to optimize optimum preparation process of 5,7,3',4'-O-tetramethylquercetin (TMQ). With 5,7,3',4'-O-tetramethylrutin as raw material, TMQ was prepared by acidic aqueous solution method. The preparation process of TMQ was optimized by single factor test and orthogonal test. The results showed that the optimum technology conditions were ethanol concentration at 0, temperature at 80℃, hydrochloric acid concentration at 0.50%, and the hydrolysis time for 1.0 h. It was concluded that the optimum preparation process had the charac-teristics of high yield, simple process, stable and feasible.
出处
《世界科学技术-中医药现代化》
北大核心
2014年第5期1182-1187,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
北京中医药大学自主选题项目(2011JYB22-XS047):基于中药有效成分的孪药设计与合成研究
负责人:李朋收