妊娠期妇女外阴阴道念珠菌感染现状

Infection status of Vulvovaginal Candidiasis in pregnant women

目的:了解妊娠期妇女外阴阴道念珠菌的种类及对抗真菌药物的敏感性,为临床预防、治疗提供有力的依据。方法:对2012-01-2012-12门诊及住院妊娠期妇女的阴道分泌物标本中分离的念珠菌进行菌种鉴定、药敏试验。结果:2 630例标本中分离出528株念珠菌,分离率20.08%,其中白念珠菌、热带念珠菌、光滑念珠菌分别占65.91%、13.70%、7.95%。念珠菌对两性霉素B、5-氟胞嘧啶、制霉菌素敏感率很高,对咪唑类出现不同程度的耐药。结论:妇女外阴阴道念珠菌患者以孕晚期为高发,白念珠菌仍是主要病原菌,非白念珠菌的比例有所上升。治疗应选用咪唑类、制霉菌素局部用药,同时采取相应的护理干预措施,可达到良好的效果。

Objective：To understand the types and antifungal susceptibility of Vulvovaginal Candidiasis（VVC） in pregnant women, in order to provide strong evidence for clinical prevention and treatment. Method：From January,2012 to December, 2012, the Candidiasis were separated from vaginal secretions of outpatients and inpatients in pregnancy, and stain identification and test of drug sensitivity were done. Result： A total of 528 Candidiasis were isolated from 2 630 specimens, isolation rate was 20.08G ,including Candida albican, Candida tropicalis, and Candida glabrata, accounting for 65.91%,13.70%a nd 7.95% respectively. Candidiasis had higher sensitive to Amphotericin B, 5-Fluoroeytosine and Nystatin, and appeared different degrees of resistance to Imidazoles. Conclusion： Patients who are in late pregnancy easily infected with VVC, and Candida albican is still a major pathogen. The proportion of non-Candida albicans increased. Treatment should be partly used with imidazoles and nystatin, while taking appropriately nursing interventions, which could achieve good effect.