基于CYP2C9靶蛋白的心血管药物个体化用药效能评价

Effectiveness evaluation of personalized medication for cardiovascular drugs based on the CYP2C9 protein

目的采用多层次模糊评价法探讨基于CYP2C9靶蛋白开发的心血管药物的效能评价。方法对作用于CYP2C9的心血管药物从多层面对个体化用药效能进行评价,建立影响药物疗效的指标体系并确定权重。结果与结论该指标体系应用于如缬沙坦一类药物的研究中,对样本的药物效能进行评分,结果符合实际药物治疗情况,得到了较好的验证,对个体化用药效能评价进行了有益的探索。

Objective To analyze the effectiveness evaluation of cardiovascular drugs which have been developed on the CYP2C9 target protein by multi-layer fuzzy evaluation technology .Methods The multi-layer fuzzy evaluation method was used to evaluate the effectiveness of cardiovascular drugs interacting with the CYP 2C9 protein and to construct the index system that affects drug efficacy .Results and Conclusion The index system was used to study such cardiovascular drugs as valsartan and to score the drug effectiveness of individual samples .The results were consistent with actual drug treatment and were well confirmed .The results contribute to evaluation of personalized medication .