乌苯美司的合成

Synthesis of Bestatin

文章以3-氨基-2-羟基-4-苯基丁酸为起始原料,经过氨基保护、酰胺缩合和脱保护等反应制得乌苯美司。此合成方法具有原料易得、条件温和、操作简单等特点。

In the paper, we report a practical synthesis ofbestatin from 3-amino-2-hudroxy-4-phenylbutyric acid. It can be converted to bestatin by N-protection, coupling with L-leucine and subsequent deprotection. The advantages of this method are cheap material, mild condition and simple operation.