蛇床子提取液对离体蟾蜍坐骨神经动作电位的影响

Effects of Cnidium monnieri(L.)cussonon compound action potential of sciatic nerve of toad

目的:研究蛇床子提取液对蟾蜍离体坐骨神经动作电位传导阻滞作用。方法:观察3种浓度蛇床子提取液(1g·ml-1、0.5g·ml-1、0.2g·ml-1)对蟾蜍离体坐骨神经复合动作电位的振幅和传导速度的影响。结果:3种浓度的蛇床子提取液均可使坐骨神经复合动作电位的振幅变小(P<0.01),传导速度变慢(P<0.01)并最终使坐骨神经动作电位消失。结论:蛇床子提取液能阻滞神经动作电位的传导。

Objective：To study the blockade effect of Cnidium monnieri（L.）cusson on action potential of sciatic nerve of toad.Methods：The influence of Cnidium monnieri（L.）cusson（1,0.5,0.2g·ml^-1）on amplitude and conduction velocity of compound action potential of sciatic nerve of toad was observed in vitro.Results：The amplitude was markedly decreased（P〈0.01）and the conduction velocity was significantly slowed down（P〈0.01）by the decoction of Cnidium monnieri（L.）cussonin three different concentrations.The action potential of sciatic nerve vanished at last.Conclusion：Cnidium monnieri（L.）cussoncould block the conduction of action potential of nerve.