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血清细胞纤维连接蛋白水平与脑出血预后的相关性分析

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摘要 目的探讨细胞纤维连接蛋白(cFN)水平对脑出血预后的预测价值。方法收集脑出血患者68例为脑出血组,同期健康体检人群50例为对照组,采用ELISA法检测2组血清cFN水平,统计分析其与脑出血后1个月死亡的相关性。结果脑出血组血清cFN水平(286.91±59.85)μg/L,对照组(165.94±38.23)μg/L,2组比较有显著性差异(P<0.01)。Logistic回归分析显示血清cFN浓度是脑出血死亡的独立危险因素。血清cFN浓度大于299.25μg/L对预测脑出血1个月内死亡的敏感性为88%,特异性为78%。结论脑出血患者血清cFN水平升高,检测血清cFN水平有助于早期判断脑出血患者的预后。
出处 《现代中西医结合杂志》 CAS 2014年第19期2137-2139,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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  • 1夏淳,张宜友,翁宇清.脑出血的流行病学研究进展[J].中国预防医学杂志,2010,11(10):1075-1077. 被引量:14
  • 2王艳红,李立明.1990-2010年我国城乡成年人群脑血管疾病死亡率的流行趋势[J].中华疾病控制杂志,2013,17(3):185-189. 被引量:42
  • 3Xi G,Keep RF, Hoff JT. Pathophysiology of brain edema formation [J]. NeurosurgClin N Am,2002,13(3):371-383.
  • 4Zhao X,Wang Y,Wang C, et al. Quantitative evaluation for second- ary injury to perihematoma of hypertensive cerebral hemorrhage by functional MR and correlation analysis with ischemic factors [ J ]. Neurol Res ,2006,28 ( 1 ) :66 - 70.
  • 5Williams CM, Engler AJ, Slone RD, et al. Fibronectin expressionmodulates mammary epithelial cell proliferation during acinar differ- entiation[J]. C Res,2008,68(9) :3185 -3192.
  • 6Lucena S,Arocha Pinango CL, Guerrero B,et al. Fibronectin Struc- ture and functions associated to hemostasis [ J ]. Invest Clin,2007, 48 ( 2 ) : 249 - 262.
  • 7Serena J, Blanco M, CasteUanos M, et al. The prediction of malig- nant cerebral infarction by molecular brain barrier disruption mark- ers [ J ]. Stroke, 2005,36 ( 9 ) : 1921 - 1926.
  • 8Castellanos M, Sobrino T, Millan M,et al. Serum cellular fibronectin and matrix metalloproteinase - 9 as screening biomarkers for the pre- diction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke : a multicenter confirmatory study [ J 3. Stroke,2007, 38(6) :1855 - 1859.
  • 9Castellanos M, Leira R, Serena J, et al. Plasma cellular fibronectin concentration predicts hemorrhagic transformation after thombolytic therapy in acute ischemic [ J ]. Stroke, 2004,35 ( 7 ) : 1671 - 1676.
  • 10庄丽丽,崔桂云,陈国芳,沈霞.血浆c-Fn与原发性脑出血早期血肿扩大关系的初步研究[J].卒中与神经疾病,2010,17(5):280-282. 被引量:2

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