纤维蛋白原和D-二聚体在妊高征中的应用价值

The clinical value of fibrinogen and D-dimer for pregnancy induced hypertension women

目的探讨正常晚孕妇女和妊娠高血压综合征(妊高征)患者血浆中纤维蛋白原(FIB)和D-二聚体(D-D)水平及其临床意义。方法采用Sysm exC A-700 0全自动血凝仪检测50 0例正常晚期妊娠孕妇(正常晚孕组)、2 0 0例妊高征孕妇(妊高征组)和100例健康育龄期非妊娠女性(正常未孕组)血浆中FIB和D-D水平。结果正常晚孕妇女、妊高征患者血浆中FIB、D-D水平分别高于健康未孕妇女,妊高征患者的FIB、D-D水平高于正常晚孕妇女,两组比较差异有统计学意义(P<0.01)。结论正常临产孕妇处于高凝状态,妊高征患者血栓前状态更明显。检测FIB、D-D对妊高征的诊断、预后评估有重要的应用价值。

Objective To explore the changes of fibrinogen（Fib） and D-dimer（D-D） in normal pregnancy and pregnancy induced hypertension（PIH） women. Methods Sysmex CA-7 000 was applied to measure the level of Fib and D-D in 500 cases of normal late pregnancy women, 200 cases of PIH women and 100 cases of non- pregnancy women. Results The level of Fib and D-D in normal late pregnancy women and PIH women were obviously higher than non-pregnancy women. The level of Fib and D-D in PIH women were ob- viously higher than normal late pregnancy women （P〈0.O1）. Conclusions Normal late pregnancy women were in hypercoagulable state, PIH women were in obvious prethrombotic state. Fib and D-D had important clinical value in diagnosis and prognosis assessment for PIH.