高血压患者动脉硬化的关联因素分析

Correlation factors of atherosclerosis in patients with hypertension

目的探讨高血压患者动脉硬化的关联因素。方法测量162例高血压患者的脉硬化指数（ASI）、血压，并检测患者的血尿酸（UA）、血糖（PG）、血脂、肌酐（Cr）、尿素氮（BUN）等血液生化指标。结果ASI增高组（n=42）患者的年龄、高血压病程、收缩压、脉压、血UA和BUN水平显著高于ASI正常组（n=120），而舒张压显著低于ASI正常组（P〈0．01，P〈0．05）。结论高血压患者动脉硬化的发生发展与年龄、高血压病程、SBP、血uA和BUN水平正相关，PP是动脉硬化程度的一种体现。

Objective To evaluate correlation factors of arteriosclerosis in patients with hypertension. Methods The arterial stiffness index （ASI）, blood pressure and the some biochemical parameters such as serum uric acid（UA）, blood glucose（BG）, blood fatty, creatinine（Cr） and urea nitrogen（BUN）, et al were measured a- mong 162 patients with hypertension. Results The patients with high arterial stiffness index possessed older age, longer hypertension duration, higher systolic blood pressure, pulse pressure difference, serum uric acid and urea nitrogenm, but lower diastolic blood pressure comparing with the patients with normal arterial stiffness index （P〈 0.01 ,P〈0.05）. Conclusion The development of arteriosclerosis in the hypertensive patients were positive corre- lated with the age, hypertension duration, systolic blood pressure, serum uric acid and urea nitrogen. Arterial stiffness may be represented by the pulse pressure difference.