摘要
目的观察不同剂量瑞舒伐他汀对急性心肌梗死(AMI)患者成功施行冠脉介入治疗(PCI)术后血管内皮功能的影响。方法选择2011年10月至2013年10月在本院确诊为冠心病、急性心肌梗死并成功行冠脉支架成形术的患者93例,分为A、B两组,A组48例,B组45例。两组患者均常规抗凝、抗血小板治疗,应用逆转心室重塑药物。A组在常规治疗基础上加用瑞舒伐他汀片10mg,B组患者在常规治疗基础上加用瑞舒伐他汀20mg。两组患者均于入院即刻,术后1d、30d时测定外周血一氧化氮(NO)、可溶性细胞间黏附分子-1(slCAM-1)、高敏C-反应蛋白(hs-CRP)及血脂水平。研究不同剂量瑞舒伐他汀对炎性指标、内皮功能及血脂的影响。结果AMI患者slCAM-1、NO、Hs-CRP水平均较正常值明显升高。10mg瑞舒伐他汀和20mg瑞舒伐他汀均可以显著降低患者slCAM-1、NO、hs-CRP水平(P均〈0.01),20mg瑞舒伐他汀较10mg瑞舒伐他汀降低slCAM-1、NO、hs—CRP水平更为显著(P均〈0.05)。结论瑞舒伐他汀可以降低血管炎性反应、改善血管内皮,大剂量的瑞舒伐他汀较常规剂量效应强。
Objective To observe the influence of different doses Rosuvastatin on endothelial function in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods A total of 93 patients with AMI after PCI were enrolled, randomly and equally divided into A, B two groups: group A in 10 mg Rosuvastatin and B group of 20 mg Rosuvastatin. Two groups of patients were routine given anticoagulation, antiplatelet and reversing ventricular remodeling medications. The levels of soluble intercellular adhesion molecule-1 (slCAM-I), nitric oxide(NO), high-sensitivity C-reactive protein(hs-CRP) and blood lipid were analyzed after 1 day and 30 days treatment. Results The level of slCAM-1, NO, hs-CRP were significantly increased after ldays treatment in both groups. The serum level of slCAM-1, NO, hs-CRP in both groups were significantly de- creased after 30 days treatment (P〈0.01). And this decrease was more significantly in B group compared to A group (P〈0.05). Conclusion Rosuvastatin may reduce vascular inflammatory reaction, improve the vascular en- dothelium, and large dose of Rosuvastatin has more stronger effect than routine dose.
出处
《中国心血管病研究》
CAS
2014年第6期539-542,共4页
Chinese Journal of Cardiovascular Research
基金
国家自然科学基金项目(项目编号:81273949/H2902)
河南省高校科技创新团队(项目编号:13IRTSTHN012):郑州市科技创新团队项目(项目编号:121PCXTD520)
关键词
急性心肌梗死
经皮冠状动脉介入治疗
内皮功能
瑞舒伐他汀
Acute myocardial infarction
Percutaneous coronary intervention
Endothelial function
Rosuvastatin