可疑AD和抑郁性假性痴呆患者功能性经颅多普勒超声的对比研究

COMPARATIVE STUDY OF FUNCTIONAL TRANSCRANIAL DOPPLER DETECTION IN SUSPICIOUS AlXHEIMER'S DISEASE AND DEPRESSIVE PSEUDO-DEMENTIA

目的:探讨可疑阿尔茨海默病(AD)患者和抑郁性假性痴呆(DPD)患者功能性经颅多普勒超声(fTCD)检测参数的差别,为AD和DPD的鉴别诊断提供新方法。方法:对可疑的AD、DPD患者及对照组各20例,分别给予阅读刺激和图像刺激后记录大脑中动脉(MCA)的血流速度,计算相对血流速度(rCBFv)来反映受试者的反应性,并比较各组差异,以期得出AD患者和DPD患者功能性TCD参数的特征和神经血管偶联作用。结果:阅读和图像刺激时,AD组、DPD组与对照组比较,平均血流速度(Vm)、rCBFv均小于对照组,搏动指数(PI)大于对照组,各指标之间的差异具有统计学意义。AD组与DPD组比较,阅读和图像时AD组MCA的Vm、rCBFv小于DPD组,且图像刺激时的变化大于阅读刺激,差异具有统计学意义。结论:AD患者和DPD患者功能性TCD检测参数不同,fTCD可作为对两者鉴别诊断的辅助方法,具有易行、经济的特点。

Objective： To investi doppler detection between Alzheimer＇s disease and provide a new method for diagnosis of AD gate the difference in parameters of functional transcranial （ AD ） and dementia depressive pseudo-dementia （ DPD ） , and DPD. Methods： The study group consisted of 20 patients suffering from DPD and 20 AD respectively, and 20 healthy controls. Reading and imagine reactivity was defined as the differences of cerebral blood flow velocity （ CBFv ） of middle cerebral artery （ MCA ） against the stimulus. Results： Subjects with AD had a lower CBFv following stimuli （P 〈 0.01 ） . Mean CBFv, velocity at rest and velocity at stimulation on MAC was significantly lower in patients with AD and DPD than those of the controls, while Pt in AD and DPD group is higher than that of controls. Compared with the controls and DPD group, the relative CBFvs （ % ） were found to be significantly lower in AD （P 〈 0.01 andP 〈 0.05, respectively ） . Conclusion： The parameters of fl＇CD detection between AD and DPD are different and fTCD are worthy popularizing in clinical to diagnosis and distinguish AD and DPD.