帕利哌酮与利培酮治疗精神分裂症的疗效及对社会功能的影响

Curative effect of paliperidone and risperidone on schizophrenia and its impact on social function

目的探讨帕利哌酮与利培酮治疗精神分裂症的疗效及对社会功能的影响。方法 2010年12月～2013年12月期间,采样抽取148例精神分裂症患者作为研究对象,并随机分为两组。对照组74例,给予利培酮治疗;实验组74例,给予帕利哌酮治疗。比较两组临床疗效及社会功能评分情况。结果实验组的显效率为93.24%（69/74）,远高于对照组的78.38%（58/74）,差异有统计学意义（P〈0.01）;实验组GQOLI-74与PANSS评分明显优于对照组,组间比较差异有统计学意义（P〈0.01）。结论帕利哌酮与利培酮治疗精神分裂症均有效,但帕利哌酮在改善患者社会功能及生活质量方面疗效更佳,值得临床推广。

Objective To investigate the curative effect of paliperidone and risperidone on schizophrenia and its impact on social function.Methods 148 cases with schizophrenia were were selected as the research object by sampling from Dec, 2010 to Dec, 2013,and they were randomly divided into the control group and the experimental group,with 74 cases in each group.The control group were treated by risperidone,while the experimental group were treated with paliperidone.Then, the clinical effect and social function of two groups were compared.Results The efficiency rate of the experimental group was 93.24% （69/74）, much higher than that of the control group which was only 78.38% （58/ 74）, so the difference was statistically significant （ P〈0.01）.The GQOLI-74 score and PANSS score of the experi- mental group were better than those of the control group, and their differences between two groups had statistical significance（ P 〈0.01）.Conclusion Both paliperidone and risperidone are effective in the treatment of schizophrenia,but paliperidone has better curative effect in improving the social function and quality of life of patients.Thus,it is worthy of clinical promotion.