阻塞性睡眠呼吸暂停低通气综合征患者P-选择素基因-2123位点多态性检测与临床分析
摘要
阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者反复呼吸暂停或低通气、夜间低氧、睡眠片段化,引起白天嗜睡、心血管系统等重要器官慢性损害。随着基因分析技术的发展,学者们注意到,在OSAHS发病中,遗传因素起到非常重要的作用。国内有报道OSAHS的发病与外周血P-选择素浓度存在相关性[1],但P-选择素基因变异在OSAHS发病中的作用如何,尚缺乏研究。
出处
《中国药物与临床》
CAS
2014年第6期782-783,共2页
Chinese Remedies & Clinics
基金
山西省卫生厅科技攻关计划项目(2011038)
参考文献6
-
1蒲娟娟,李涛,欧阳松云,李华.老年高血压病合并OSAHS患者nCPAP治疗前后血小板活性及P选择素水平的变化[J].中国实用医药,2008,3(15):70-71. 被引量：1
-
2明凯华,李艳,夏尊恩,熊小泉.中国汉族人群P-选择素基因多态性的研究[J].临床检验杂志,2006,24(4):285-288. 被引量：10
-
3McEver RP,Beckstead JH,Moore KL,et al.GMP-140,a platelet alpha-granule membrane protein,is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies[J].J Clin Invest,1989,84(1):92-99.
-
4Dole VS,Bergmeier W,Mitchell HA,et al.Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo:role of P-selectin[J].Blood,2005,106(7):2334-2339.
-
5Shimizu M,Kamio K,Haida M,et al.Platelet activation in patients with obstructive sleep apnea syndrome and effects of nasalcontinuous positive airway pressure[J].Tokai J Exp Clin Med,2002,27(4):107-112.
-
6Bots ML,Elwood PC,Nikitin Y,et al.The EUROSTROKE cohorts:a short description and data analytical approach[J].J Epidemiol Community Health,2002,56 Suppl 1:i2-7.
二级参考文献15
-
1[1]Elmasry A,Lindberg E,Hedner J,et al.Obstructive sleep apnea and urine catecholamines in hypertensive males:a population based study.Eur Respir J,2002,19(3):511.
-
2[4]Suzuki M,Kamio K,Kaida Y,et al.Platelet activation in patients with obstructive sleep apnea syndrom and effect of nasal-continuous positive airway pressure.Tokai J Exp Clin Med,2002,27(40):107-122.
-
3[5]Bots ML,Elwood PC,Nikitin Y,et al.The UROSTROKE cohorts:a short descirption and data analytical approach.J pidemiol Community Health,2002,56(1):12-17.
-
4[6]Gurbel PA,O'Connor CM,Dalesandro MR,et al.Relation of soluble and platelet P2selectin to early outcome in patients with acute myocardial infarction after thrombolytic therapy.AmJ Cardiol,2001,87(6):774-776.
-
5Barbaux C.Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery diseases[J].Arterioscler Thromb Vasc Biol[J],2001,21(10):1668-1673.
-
6Stefan-Martin Herrmann,Sylvain Ricard,Viviane Nicaud1,et al.The P-selectin gene is highly polymorphic:reduced frequency of the Pro715 allele carriers in patients with myocardial infarction[J].Hum Mol Genet,1998,7(8):1277-1284.
-
7Carter A M,Anagnostopoulou K,Mansfield M W,et al.Soluble P-selectin levels,P-selectin polymorphisms and cardiovascular disease[J].J Thromb Haemost,2003,1(8):1718-1723.
-
8Wu G X,Li F G,Li P X,et al.Detection of plasma а-guanule menbrane protein(GMP-140) using radiolabeld monoclonal antibodies in thrombotic disease[J].Haemostasis,1993,23(2):121-128.
-
9Nagashima M,Shin'Oka T,Nouert G,et al.Effects of a monoclonal antibody to P-selection on recovery of neonatal hearts after cold cardioplegic ischemia[J].Circulation,1998,98(19 suppl):Ⅱ391.
-
10Zingarelli B,Salzman A L,Szabo C.Genetic disruption of poly (AD-Pribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecular in myocardial ischemia/reperfusion injury[J].Circ Res,1998,83(1):85-94.
共引文献9
-
1邹伟华,顾金华,胡小芹.原发性肾小球肾炎患者外周血血小板P-选择素检测的临床意义[J].检验医学,2009,24(6):452-454.
-
2韩美玉,杨文东.急性脑梗死患者可溶性P-选择素与高敏C-反应蛋白的相关性研究[J].实用心脑肺血管病杂志,2010,18(10):1398-1399. 被引量：1
-
3秦静静,张蕴莉.选择素及其基因多态性与冠心病的关系[J].山东医药,2010,50(49):111-113.
-
4孙晓军,杨文东,马庆海.2型糖尿病合并冠心病患者可溶性P选择素与超敏C反应蛋白的相关性研究[J].国际检验医学杂志,2011,32(1):116-117. 被引量：16
-
5张学民,杨文东.急性脑梗死患者治疗前后血清脂联素和P-选择素水平变化[J].实用心脑肺血管病杂志,2011,19(2):195-196. 被引量：2
-
6李晶,王一冰,刘华林,蒋玉红,刘薇,王亚秋.过敏性紫癜P-选择素基因-2123位点多态性检测与临床分析[J].中国当代儿科杂志,2011,13(4):278-281. 被引量：8
-
7罗玉丽.P-选择素基因多态性与P-选择素蛋白关系的研究进展[J].海峡科学,2011(9):15-16.
-
8罗玉丽,林翠云.P-选择素基因多态性及临床研究进展[J].福建医药杂志,2011,33(6):155-157. 被引量：4
-
9尹富禹,卢欣,吴晓鹏.P-选择素基因多态性对冠心病患者PCI术后血小板抑制率、MA-ADP及血小板活化指标的影响[J].中国循证心血管医学杂志,2018,10(12):1523-1526. 被引量：10
-
1王金凤,尹燕坤,姜荣刚,孙庚芬,孙健.成人耳聋患者BAEP的检测与临床意义[J].实用医技杂志,1997,4(9):661-662.
-
2口吃与基因有关[J].新疆医药保健,2002(12B):55-55.
-
3章诗富,成丽兰,徐军发.变应性鼻炎患者血浆P-选择素的测定及其意义[J].临床耳鼻咽喉科杂志,2003,17(5):275-276. 被引量：4
-
4曹海萍.多导睡眠图夜间监测诊断阻塞性睡眠呼吸暂停低通气综合征患者的护理观察[J].中国实用护理杂志（中旬版）,2008,24(1):24-25.
-
50SAS患者睡眠时体内血小板活性增加[J].中华医学信息导报,2002,17(15):9-9.
-
6陈军,马美,明昊,胡愈强,刘冰,程良军.单纯鼻部手术对伴有鼻阻的阻塞性睡眠呼吸暂停低通气综合征患者睡眠的影响[J].中国耳鼻咽喉头颈外科,2017,24(2):105-106. 被引量：2
-
7张秀琴,刘仍允,黄建安,胡华成.阻塞性睡眠呼吸暂停综合征的潜在遗传易感性因素[J].国际呼吸杂志,2008,28(6):353-356.
-
8韩剑星,吕声锐,董俊平,马瑗,刘燕.血红素氧合酶1基因-413A/T位点多态性与阻塞性睡眠呼吸暂停低通气综合征相关性研究[J].中国药物与临床,2014,14(4):452-454. 被引量：4
-
9余洪猛,张重华.细胞粘附分子与鼻息肉研究进展[J].中国眼耳鼻喉科杂志,2001,1(2):119-120.
-
10朱晓燕,魏钦俊,鲁雅洁,王荷溪,陈智斌,曹新,邢光前.耳聋分子病因学检测与临床应用研究[J].南京医科大学学报（自然科学版）,2013,33(2):186-190. 被引量：11
