TGF-β信号通路与口腔鳞状细胞癌的研究进展

Research progress about role of TGF-β signaling pathway in oral squamous cell carcinoma

转化生长因子β(TGF-β)是一个调节上皮细胞增殖、免疫功能和新血管生成的关键分子,TGF-β及其信号通路在维持上皮细胞内环境稳态时发挥重要作用。TGF-β信号通路的失调在众多恶性肿瘤中均可见,包括口腔鳞状细胞癌(OSCC)。TGF-β信号通路的失调会导致细胞过度增殖并抑制细胞凋亡,基因组不稳定性增强,促进肿瘤上皮间质转化。而肿瘤炎症微环境中TGF-β会代偿性升高,提高肿瘤细胞的增殖及迁移能力,促进癌巢内的新血管生成,增强炎症对肿瘤的促进作用。本文就TGF-β信号通路在OSCC发生、发展中所发挥的作用做一综述。

Transforming growth factor-β （TGF-β） is a key regulator of epithelial cell proliferation,immune function and angiogenesis.Because TGF-β signaling maintains epithelial homeostasis,dysregulated TGF-β signaling is common in many malignancies,including oral squamous cell carcinoma （OSCC）.Defective TGF-β signaling in epithelial cells causes hyperproliferation,reduced apoptosis and increased genomic instability,and the compensatory increase in TGF-β production by tumor epithelial cells with TGF-β signaling defects further promotes tumor growth and metastases by increasing angiogenesis and inflammation in tumor stromal cells.We review the role of TGF-β signaling in the development of OSCC.