新鲜冰冻血浆的临床应用

Application of fresh plasma in clinical treatment

目的调查本血站新鲜冰冻血浆的临床应用情况。方法选取2012年10月至2013年10月于我站接受新鲜冰冻血浆输注治疗的624例患者为研究对象,分析其输注目的,并将患者按照新鲜冰冻血浆输注适应证标准,分至控制组和非控制组,比较两组患者输注前后8h内的PT及APTT。结果新鲜冰冻血浆合理输注目的为血栓性血小板减少性紫癜、血浆置换、补充多种获得性凝血因子缺乏,占65.71%,不合理输注目的占34.29%,以补充蛋白质、扩容、促进伤口愈合为主,分别占12.51%、8.49%、8.17%。控制组患者输注后APTT、PT较输注前明显缩短,输注前后差异均具有统计学意义(P<0.05);非控制组患者输注后APTT、PT较输注前有一定缩短,但输注前后差异无统计学意义(P>0.05)。结论新鲜冰冻血浆的合理使用有利于纠正由于凝血因子缺乏所致的出血,但其不合理使用现象临床普遍存在,医院输血科应发挥自身特长,通过培训等途径不断提高新鲜冰冻血浆的合理使用水平。

Objective To investigate the clinical application of fresh frozen plasma in the blood transfusion.Methods The patients accepted fresh frozen plasma infusion in the blood transfusion were selected, the objective of infusion was analyzed, and patients were divided into control group and non control group with fresh frozen plasma transfusion indication, the APTT and PT of before injection and within 8 hours post injection were compared.Results Fresh frozen plasma reasonable infusion for thrombotic thrombocytopenic purpura, plasma exchange, added a variety of acquired coagulation factor deficiency, accounting for 65.70%, unreasonable infusion objective accounted for 34.30%, to supplement the protein, expansion, promote wound healing, accounted for 12.51%, 8.49%, 8.17%, respectively, Control group patients after infusion of APTT, PT before infusion was significantly shorter than before and after infusion, with significant difference（P〈0.05）; non control group patients after infusion of APTT, PT than before infusion was shortened, but before and after the infusion had no significant differences. Conclusion The rational use of fresh frozen plasma is advantageous to correct coagulation factor deficiency caused by bleeding, but the irrationaluse of clinical phenomenon exists generally, blood transfusion, the hospital should give full play to our own advantages,through training and other ways to improve the rational use of fresh frozen plasma level.