柠檬酸色谱分离的动力学模拟

The Dynamic Simulation of Chromatographic Separation of Citric Acid

报道一种在考虑柱床空隙率变化的条件下变温色谱动力学研究和参数测定的方法 .以柠檬酸的提纯分离为实验例子 ,在分析柱上测定各模型参数 ,用这些热力学参数加入到平衡分散模型中 ,模拟在大型生产柱上的动力学行为 。

This paper provides a suitable method for studying thermal swing chromatographic kinetics and estimation of model parameters, considering the change of bed porosity. As an experimental example, the separation of the citric acid is discussed. The model parameters were measured on an analytical column. With these thermodynamic parameters it was attempted to simulate the separation behaviour in larger columns using the equilibrium dispersive model, the result was very satisfactory.