摘要
自噬是细胞对内外界环境压力变化的一种反应,是细胞内的物质成分被溶酶体降解的过程。近年研究发现自噬在2型糖尿病的发生发展中起着重要作用,与胰岛β细胞的数量和胰岛素的分泌密切相关,是一种细胞的自我保护机制,自噬的激活与调节对于维持胰岛β细胞的结构和功能方面必不可少。此外,研究发现一些治疗2型糖尿病的药物也参与了自噬途径的调节。因此,本文就自噬在维持胰岛β细胞结构和功能中重要作用,自噬通路的调节,以及自噬与2型糖尿病药物的相关性等方面进行综述。
Autophagy is a cellular reaction to the changes of internal and external environmental pressure, and a degradation process of the material composition. Recent study has shown that autophagy is closely related to the quantity and insulin secretion of pan- creatic β cell. As a self-protection mechanism, the activation and regulation of autophagy are essential for maintaining the structure and function of pancreatic β cells in type 2 diabetes. Moreover, some drugs for type 2 diabetes were found to participate in the regulation of autophagy pathway in recent studies. Thus, in this review we summarize the importance of autophagy in protecting the structure and func- tion of pancreatic β cell, the regulation of autophagy pathway and the correlation between autophagy and drugs for type 2 diabetes.
出处
《国际药学研究杂志》
CAS
CSCD
2014年第3期301-306,共6页
Journal of International Pharmaceutical Research
基金
国家自然科学基金资助项目(81260502)
云南省教育厅科学研究基金重点资助项目(2012Z081)
关键词
2型糖尿病
胰岛B细胞
自噬通路
type 2 diabetes
pancreatic βcell
autophagy signal pathway