输卵管阻塞性不孕症宫腹腔镜术后应用欣可聆插管通液效果观察

Hin ceruminous tube-pass fluid applied for salpinx obstructive infertility after hysteroscopy operation

[目的]观察输卵管阻塞性不孕症宫腹腔镜联合术后,用欣可聆注射液进行彩色超声引导下宫腔镜输卵管插管通液的临床效果。[方法]选择宫腹腔镜术后至少一侧输卵管通畅的不孕症患者160例,按入院先后依次编入观察组和对照组,每组80例,观察组术后第1次月经干净后3-7 d应用欣可聆注射液,行彩色超声引导下宫腔镜输卵管插管通液;对照组不给予任何药物,采取期待疗法。比较两组术后1年妊娠情况。术后1年未妊娠者,于月经干净后3-7 d行子宫输卵管碘佛醇造影检查,观察比较两组输卵管通畅情况。[结果]术后1年,观察组正常宫内妊娠率为68.75%高于对照组的51.25%,差异有统计学意义（χ^2=5.104,P=0.024）;两组异位妊娠率比较,差异无统计学意义（P〉0.05）;观察组未妊娠者输卵管双侧通畅率为40.9%,显著高于对照组的14.2%（P〈0.05）;双侧不通发生率为9.1%,非常显著低于对照组的42.8%（P〈0.01）;两组总通畅率比较,差异无统计学意义（P〉0.05）。[结论]输卵管阻塞性不孕症宫腹腔镜联合术后第1次月经干净后3-7 d,用欣可聆注射液行彩色超声引导下宫腔镜输卵管插管通液,可以降低盆腔的再次粘连,维持输卵管的通畅,提高妊娠率,可以作为宫腹腔镜术后的后续治疗方法,值得临床推广应用。

Objective To study the clinical effect of Hin ceruminous injection after uterine lapa-roscopy combined operation in treatment of salpinx obstructive infertility ,which was done under the guidance of color Doppler ultrasound . [ Methods] A series of 160 salpinx obstructive infertility patients were in-cluded and randomly divided into the treatment group （ n=80 , treated with Hin ceruminous injection under the guidance of Color ultrasound 3-7 days after the first Menstrual cycle following hysteroscopy operation ） and the control group （ n=80 , treated by expectant method ） .The pregnancies were compared in the two groups 1 year after operation .The unpregnant patients were given Ioversol check 3 to 7 days after menstrua-tion clean to compare patency conditions of Fallopian tube between the two groups . [ Results] One year after operation the normal intrauterine pregnancy rate was 68.75%,which was higher than 51.25% in the control group .The difference was significant between the two groups （χ^2 =5 .104 , P =0 .024 ） .Ectopic pregnancy rates were compared between the two groups and the difference was not significant （P〉0.05）. The patency rate of bilateral fallopian tubes in unpregnant patients of the observation group was 40 .9%, which was remarkably higher than 14.2%in the control group （P〈0.05）.And the incidence of impotency was 9.1%,which was markedly lower than 42.8%in the control group（P〈0.01）.And comparison of the total patency rates showed that the difference between the two groups was not significant （ P〉0 .05 ） . [ Conclusion] Hin ceruminous injection after Hysteroscopy operation in treatment of salpinx obstructive infertility is effective and safe .