精神分裂症合并乙肝患者用药情况分析

Analysis of medication situation for patients with schizophrenia combined with hepatitis B

目的:对80例住院精神分裂症合并乙肝患者的临床精神科用药状况进调查。方法:自行设计调查表,对入选的精神分裂症合并乙肝患者使用药物的情况进行调查、统计及分析。结果:单一用药所占比例最大为56例(使用频度达70%),其中以氯氮平和喹硫平最为常用(使用频度分别为44.6%和16.1%),其它依次为利培酮(12.5%)、奥氮平(10.7%)、舒必利(7.1%)、阿立哌唑(3.6%)、奋乃静(3.6%)、帕利哌酮(1.78%)。联合用药者共24例(30%),均为二联用药,其中以氯氮平+阿立哌唑使用最多(使用频度达41.67%),其它主要联合用药为氯氮平+利培酮(12.5%)、奥氮平+利培酮(8.33%)、利培酮+喹硫平(8.33%)。结论:非典型抗精神病药逐渐取代典型抗精神病药,对于精神分裂症合并乙肝的患者来说,氯氮平、奥氮平通常不作为首选。

Objective：To investigate the clinic psychiatry drugs for 80 inpatients with schizophrenia combined hepatitis B in our hospital.Methods：The clinic psychiatry drug situations of the patients with schizophrenia combined hepatitis B were investigated with a self-designed questionnaire and statistically analyzed.Results：The results showed that the number of the single drug was 56,which was the largest proportion among the 80 inpatients（the frequency was 70%）.The most common used drugs were clozapine and quetiapine（44.6% and 16.1%）,followed by risperidone（12.5%）,olanzapine（10.7%）,sulpiride（7.1%）,aripiprazole（3.6%）,perphenazine（3.6%）,and palipefidone（1.78%）.The number of the drug combination was 24（30%）.Two-drug was used without three-drug.The clozapine combined with aripiprazole accounted for the most（41.67%）,clozapine combined with risperidone was 12.5%,olanzapine combined with risperidone was 8.33%,and risperidone combined with quetiapine was 8.33%.Conclusions：Non-classical antipsychotics is replacing the classical antipsychotics in the treatment of schizophrenia.Clozapine and olanzapine are not usually used as the first choices for treating schizophrenia combined hepatitis B.