肿瘤坏死因子与白细胞介素-8在不同类型冠心病患者中的表达水平

Expression levels of TNF-α and IL-8 in coronary heart disease

目的探讨不同类型冠心病患者肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)的表达水平及临床意义。方法选取冠心病患者120例为研究对象,根据临床诊断类型分为稳定型心绞痛组43例、不稳定型心绞痛组37例和急性心肌梗死组40例,另选取健康体检者40例为对照组,对比各组TNF-α、IL-8的表达水平。结果冠心病患者血清TNF-α和IL-8水平高于对照组(P<0.01),其中急性心肌梗死组最高,其次为不稳定型心绞痛组和稳定型心绞痛组(P<0.01);多支病变组TNF-α和IL-8水平高于双支病变组和单支病变组(P<0.01),而双支病变组高于单支病变组(P<0.01);中度狭窄组TNF-α和IL-8水平高于轻度狭窄组(P<0.01),重度狭窄组TNF-α和IL-8水平高于中度狭窄组和轻度狭窄组(P<0.01)。结论冠心病患者血清TNF-α和IL-8水平显著升高,且疾病严重程度越重,其水平越高,可作为临床评估疾病程度的标志之一。

Objective To discuss clinical value and expression levels of TNF-α and IL-8 in coronary heart disease. Methods One hundred and twenty cases with coronary heart disease selected as study subjects were divided into SAP group（ n = 43）,UAP group（ n = 37） and AMI group（ n = 40） according to diagnosis. Forty healthy volunteers were selected as control group. TNF-α and IL-8 were compared. Results Levels of TNF-α and IL-8 in coronary heart disease group were higher than those of control group（ P〈0.01）. The level of AMI group was the highest,followed by UAP group and SAP group（ P〈0.01）. Levels of TNF-α and IL-8 in multiple pathological change group was higher than that of the double group（ P〈0.01）,which was higher than that of the single group（ P 0.01）; Levels of TNF-α and IL-8 of medium stenosis group was higher than that of the light stenosis group（ P 0.01）,but the severe group was higher than that of the medium and light groups（ P〈0.01）. Conclusion Levels of TNF-α and IL-8 in patients with coronary heart disease are significantly increased with the aggravation of the disease and they can be seen as one of the indicators of the severity of the disease.