摘要
目的:探讨多奈哌齐合并复方海蛇胶囊对阿尔茨海默病(AD)患者认知功能和行为能力的改善作用。方法:90例AD患者随机分为3组:联合治疗组(给予多奈哌齐合并复方海蛇胶囊治疗)30例、多奈哌齐治疗组(单用多奈哌齐治疗)30例、对照组(仅予常规治疗,不予痴呆药物)30例。观察3个月。分别在治疗前和治疗3个月后采用简易精神状态检查量表(MMSE)及日常生活能力量表(ADL)测评3组患者的认知功能和生活能力。结果:治疗3个月,联合治疗组MMSE减分值明显高于多奈哌齐治疗组(t=5.09,P<0.01)和对照组(t=7.71,P<0.01);多奈哌齐治疗组减分值明显高于对照组(t=3.10,P<0.01)。联合治疗组ADL评分减分值明显高于多奈哌齐治疗组(t=-2.33,P=0.02)和对照组(t=-6.88,P<0.01);多奈哌齐治疗组减分值明显高于对照组(t=-5.50,P<0.01)。结论:多奈哌齐和复方海蛇胶囊联合治疗对AD患者的认知功能及行为能力有显著的改善作用。
Objective:To investigate the improving effect of cognitive function and behavioral abilities with therapy of the combination of donepezil and compound Haishe capsule on Alzheimer′s disease(AD). Method:Totally 90 AD patients were randomly divided into 3 groups:combination treatment group(treated with donepezil and compound Haishe capsule)30 cases;donepezil group(treated with donepezil alone)30 cases;and the control group(conventional treatment without any anti-dementia drug)30 cases. The patients in the 3 groups were assessed by Mini mental state examination(MMSE)scale and the activity of daily living(ADL) scale before treatment and 3 months after treatment. Results:The decreased score of MMSE in combination treatment group was markedly higher than donepezil group(t = 5. 09,P ﹤ 0. 01)and control group(t = 7. 71, P ﹤ 0. 01);which in donepezil group was markedly higher than control group(t = 3. 10,P ﹤ 0. 01). The de-creased score of ADL in combination treatment group was markedly higher than that of donepezil group (t = - 2. 33,P = 0. 02)and the control group(t = - 6. 88,P ﹤ 0. 01);with in donepezil group were markedly higher than the control group( t = - 5. 50,P ﹤ 0. 01). Conclusion:Donepezil combined with compound Haishe capsule can improves cognitive function and behavioral abilities in AD patients significantly.
出处
《临床精神医学杂志》
2014年第3期201-202,共2页
Journal of Clinical Psychiatry