(S)-2,2-二甲基环丙烷甲酰胺合成研究进展

Research Progress in the Synthesis of(S)-2,2-Dimethylcyclopropanecarboxamide

西司他丁是目前临床上广泛使用的广谱抗菌药泰能的重要组分,(S)-2,2-二甲基环丙烷甲酰胺是合成西司他丁的关键中间体,目前已有多种合成方法见诸文献。综述了近年来(S)-2,2-二甲基环丙烷甲酰胺的各种合成方法,对其进行了简要评述,并对今后的发展方向进行了展望。

Cilastatin is an important component of tienam, a widely-used broad-spectrum antimicrobial drug. （S）-2,2-dimethylcyclopropanecarboxamide is a key intermediate in the production of cilastatin, and many synthetic methods have been reported in the last years. In this paper, various symhetic methods of （S）-2,2-dimethyl-cyclopropanecarboxamide has been reviewed and commented. In the end, the future development trend of （S）-2,2-dimethylcyclopropanecarboxamide has been prospected.