血必净治疗重症脓毒症和脓毒症休克的临床疗效分析

Clinical Curative Effect of Xuebijing in the Treatment of Severe Sepsis and Septic Shock

目的探讨血必净治疗重症脓毒症和脓毒症休克的临床疗效。方法入选2010年1月至2013年12月我院收治的126例重症脓毒症和脓毒症休克患者,随机分为试验组和对照组。对照组60例采用常规治疗措施,试验组66例在对照组基础上加用血必净治疗。比较两组患者病死率的差异,并评价患者APACHEⅡ评分情况。结果试验组治疗后病死率为18.1%显著低于对照组38.3%,有统计学差异(P<0.05);治疗后试验组APACHE II评分显著下降,有统计学差异(P<0.05),且明显低于同期对照组,有统计学差异(P<0.05)。结论血必净治疗重症脓毒症和脓毒症休克疗效显著,能够显著降低患者临床病死率,促进患者恢复,提高其生活质量。同时,能明显降低患者APACHEⅡ评分,缓解病情严重度,提高患者健康生理状态,值得临床选择。

Objective To investigate the clinical curative effect of Xuebijing in the treatment of severe sepsis and septic shock. Methods 126 patients with severe sepsis and septic shock treated in our hospital from January 2010 to December 2013 were selected and randomly divided into the experimental group and the control group. 60 patients in the control group received routine treatment, and 66 cases in the experimental group were treated with Xuebijing in additional to the routine therapy. The primary outcome was a composite of a comparison of the difference in mortality between the two groups, and an evaluation of patients＆#39; APACHE II score. Results The mortality rate of the experimental group after treatment was 18.1%, significantly lower than that of the control group （38.3%）, with significant difference （P〈0.05）. And the APACHEIIscore of the experimental group after treatment decreased remarkably （P〈0.05）, significantly lower than that of the control group （P〈0.05）. Conclusions Applying Xuebijing in the treatment of severe sepsis and septic shock has profound effect, which can significantly reduce the mortality rate, enhance patients＇; recovery, improve the quality of life. Meanwhile, it can significantly reduce patients＆#39; APACHEIIscore, relieve patients＇; condition, improve patients＆#39; physiological state. It is worthy to be applied clinically.