干燥综合征合并间质性膀胱炎3例并文献复习

Sjgren's Syndrome Complicated with Interstitial Cystitis:3 Cases Reports with Literature Review

目的总结分析干燥综合征(Sjgren’s syndrome,SS)合并间质性膀胱炎(interstitial cystitis,IC)患者的临床特征、治疗方案及预后。方法报道北京协和医院近年来治疗的3例SS合并IC患者的病例资料。结果 3例患者均为女性,均有尿频、尿急、尿痛等尿路刺激症状,发病初期均怀疑为尿路感染,反复应用抗生素治疗无效,其中2例SS患者以IC为首发表现。3例患者均无明显的尿路梗阻及假性肠梗阻症状。药物治疗以糖皮质激素及免疫抑制剂为主,症状多在2周后减轻,晚期严重患者需手术治疗。结论 SS合并IC多见于中老年女性,以尿路刺激症状为主要表现,激素、免疫抑制剂治疗有效,临床上易被误诊、漏诊,当SS患者出现反复尿路刺激症状时,要考虑到IC可能。

To analyze the clinical features of Sj？gren’s syndrome （SS）complicated with Interstitial cystitis（IC）.Methods Three patients of SS complicated with IC admitted to PUMCH were retrospectively analyzed.Results Three patients were all female.All patients complained of urinary frequency,urgency and suprapubic pain.Before the diagnosis of IC was defined,all patients were misdiagnosed as infective diseases.The initial symptoms of 2 patients of SS were IC symptoms.Treatments such as glucocorticsteroid and immunosuppressive agents,could relieve the symptom in about 2 weeks later.Conclusions Patients of SS complicated with IC primarily manifest with urinary frequency and urgency.It’s easy to be misdiagnosed as urinary tract infection.In order to be treated early,IC should be considered when patients with SS complain of recurrent urinary discomfort.