心衰宁不同剂型对血流动力学的影响

Hemodynamic Effects of Different Dosage Forms of Xinshuaining Granules

目的:探讨心衰宁汤剂和颗粒剂对SD大鼠实验致心力衰竭的影响与作用机制。方法:实验分3大组,实验组、安慰剂组和空白对照组。实验组和安慰剂组采用盐酸阿霉素致慢性心力衰竭的大鼠模型。实验组给予不同剂型的心衰宁汤剂3.6 g·kg-1,心衰宁颗粒7.2,3.6,1.8 g·kg-1ig,1次/d,连续15 d,空白组及安慰剂组给予生理盐水15 d,给药完毕后,压力传感器记录左心室血流动力学改变,测定心脏系数等。结果:不同剂型的心衰宁制剂均能改善慢性心衰大鼠血流动力学各项指标。提高慢性心衰大鼠的左室内压(LVSP),降低左心室舒张末压(LVEDP),改善左室内压变化速率±dp/dtmax,显著降低心脏系数;且考察指标以心衰宁颗粒剂高剂量组最为明显。结论:心衰宁颗粒和汤剂均改善慢性心衰大鼠的血流动力学,其机制可能与抗肌纤维化及逆转心肌肥厚有关。

Objective： To explore the influence and mechanism of Xinshuaining granules and decoction in the treatment of experiment heart failure in rats. Method： Rats were divided into 3 groups, treatment group, placebo group and control group. The chronic heart failure （CHF） model was caused by doxorubicin hydroehloride. The treatment group was given Xinshuaining granules and decoction for 15 days, and the control group and placebo group were given physiological saline for 15 days. After administration, the hemodynamie changes were recorded. Result： The Xinshuaining granules and decoction improved cardiac hemodynamic parameters, including left ventricular systolic pressuer （LVSP）, left ventricular end-diastolic pressuer （LVEDP）, ± dp/dt and significantly decreased cardiac coefficient. Conclusion： Xinshuaining granules and decoction can improve the cardiac hemodynamic parameter of CHF rats.