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心衰宁不同剂型对血流动力学的影响 被引量:7

Hemodynamic Effects of Different Dosage Forms of Xinshuaining Granules
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摘要 目的:探讨心衰宁汤剂和颗粒剂对SD大鼠实验致心力衰竭的影响与作用机制。方法:实验分3大组,实验组、安慰剂组和空白对照组。实验组和安慰剂组采用盐酸阿霉素致慢性心力衰竭的大鼠模型。实验组给予不同剂型的心衰宁汤剂3.6 g·kg-1,心衰宁颗粒7.2,3.6,1.8 g·kg-1ig,1次/d,连续15 d,空白组及安慰剂组给予生理盐水15 d,给药完毕后,压力传感器记录左心室血流动力学改变,测定心脏系数等。结果:不同剂型的心衰宁制剂均能改善慢性心衰大鼠血流动力学各项指标。提高慢性心衰大鼠的左室内压(LVSP),降低左心室舒张末压(LVEDP),改善左室内压变化速率±dp/dtmax,显著降低心脏系数;且考察指标以心衰宁颗粒剂高剂量组最为明显。结论:心衰宁颗粒和汤剂均改善慢性心衰大鼠的血流动力学,其机制可能与抗肌纤维化及逆转心肌肥厚有关。 Objective: To explore the influence and mechanism of Xinshuaining granules and decoction in the treatment of experiment heart failure in rats. Method: Rats were divided into 3 groups, treatment group, placebo group and control group. The chronic heart failure (CHF) model was caused by doxorubicin hydroehloride. The treatment group was given Xinshuaining granules and decoction for 15 days, and the control group and placebo group were given physiological saline for 15 days. After administration, the hemodynamie changes were recorded. Result: The Xinshuaining granules and decoction improved cardiac hemodynamic parameters, including left ventricular systolic pressuer (LVSP), left ventricular end-diastolic pressuer (LVEDP), ± dp/dt and significantly decreased cardiac coefficient. Conclusion: Xinshuaining granules and decoction can improve the cardiac hemodynamic parameter of CHF rats.
作者 曾真 张永萍
机构地区 贵阳中医学院
出处 《中国实验方剂学杂志》 CAS 北大核心 2014年第13期169-171,共3页 Chinese Journal of Experimental Traditional Medical Formulae
基金 贵州省中药民族药炮制与制剂工程技术研究中心(黔科合重G字[2012]4001)号
关键词 心衰宁颗粒 心衰宁汤剂 盐酸阿霉素 血液动力学 Xinshuaining granules Xinshuaining decoction doxorubicin hydrochloride hemodynamics
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  • 1万发银,王挹青,陈炳煌,王焱,黄卫斌,刘文辉,叶涛.稳心颗粒治疗室性早搏70例疗效观察[J].中西医结合心脑血管病杂志,2005,3(12):1099-1100. 被引量:2
  • 2李明诗,谭莹,潘洁,彭世揆.结合光谱、纹理及地形特征的森林生物量建模研究[J].遥感信息,2006,28(6):6-9. 被引量:38
  • 3Hasenfuss G. Animal model of human cardiovascular disease, heart failure and hypertrophy[J]. Cardiovasc Res, 1998, 39(1):60-76.
  • 4Smith HJ, Nuttall AA, Experimental models of heart failure[J].Cardiovase Res, 1985, 19(4): 181-186.
  • 5Bing OH, Brooks WW, Conrad CH, et el. Intracellular calcium transients in myocardium from spontaneously hypertensive rats during the transition to heart failure[J]. Cire Res, 1991, 68(5): 1390-1400.
  • 6Weinberg EO, Schoen FJ, George D, et al. Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis [J]. Circulation, 1994, 90(3): 1410-1422.
  • 7Armal JF, Philippe M, Laboulandine I, et al. Effect of perindopril in rat caxdiac volume overload[Jl. Am Heart J, 1993, 126(3):776-782.
  • 8Underwood RD, Aarhus LL, Heublein DM, et al. Endothelin in thoracic inferior vena caval constriction model of heart failure[J]. Am J Physiol, 1992, 263(3):H951-H955.
  • 9Wilson JR, Douglas P, Hickey WF, et al. Experimental congestive heart failure produced by rapid ventricular pacing in the dog: Cardiac effects [J]. Circulation, 1987, 75(4):857-867.
  • 10Dibner-Dunlap ME, Thames MD. A simplified technique for the production of heart failure in the dog by rapid ventricular pacing[J].Am J Med, 1990, 300(5):288-290.

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