大叶胡颓子叶止咳作用的研究

Cough-relieving Effect Research of Elaeagnus macrophylla Thunb.leaves

目的探讨大叶胡颓子叶的止咳作用,比较不同极性部位的止咳效果。方法大叶胡颓子叶经乙醇提取得到粗提物,再用系统试剂萃取分离得到不同极性的部位。采用氨水引咳法分别对粗提物和氯仿部、乙酸乙酯部、正丁醇部、水部4个部位进行止咳试验。结果大叶胡颓子叶具有显著的止咳作用,粗提物在40 mg/kg的低剂量时就表现出与阳性对照一样的止咳效果。不同部位的止咳效果不同,乙酸乙酯部、水部的止咳作用最强,正丁醇部次之,氯仿部的止咳作用较弱。结论大叶胡颓子叶止咳作用显著,是滨海盐碱地生长的良好中药材。

Objective To study the leaves of Elaeagnus macrophylla and Cough - relieving effects of different Polar site. Methods The ethanol extracts of leaves of Elaeagnus ma^rophylla are extracts and extraction system reagents are parts of different polarity. Ammonia water induced cough law definitions of crude extracts and chloroform and ethyl acetate, n - butanol, water Department 4 positions cough test. Results Leaves of Elaeagnus macrophylla has significant cough, extracts in 40mg/kg at low doses is showed antitussive effects with positive control. Antitussive effects in different parts of different cough effect of ethyl acetate,water Depart- ment are the strongest, followed by n -butyl alcohol, chloroform cough is weak. Conclusion The leaves of Elaeagnus rm^rophylla antitussive effect is remarkable, is the growth of coastal saline - alkali soil of good Chinese herbal medicines.